diff --git a/CHANGELOG.md b/CHANGELOG.md
index 9091791ea7..c57f7f373b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -22,6 +22,7 @@ This component adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.h
   traces instrumentation for versions `1.8.0`+.
 - Support for `temporality_preference` in file-based configuration
   for Console Metric Exporter.
+- Enable ASLR, CET and CFG for native profiler libraries on Windows.
 
 ### Changed
 
diff --git a/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.DLL.vcxproj b/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.DLL.vcxproj
index 2a8bdd3df9..ee707a1706 100644
--- a/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.DLL.vcxproj
+++ b/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.DLL.vcxproj
@@ -40,6 +40,7 @@
     <PlatformToolset>v143</PlatformToolset>
     <WholeProgramOptimization>true</WholeProgramOptimization>
     <CharacterSet>Unicode</CharacterSet>
+    <LinkControlFlowGuard>true</LinkControlFlowGuard>
   </PropertyGroup>
   <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Debug|x64'" Label="Configuration">
     <ConfigurationType>DynamicLibrary</ConfigurationType>
@@ -53,6 +54,7 @@
     <PlatformToolset>v143</PlatformToolset>
     <WholeProgramOptimization>true</WholeProgramOptimization>
     <CharacterSet>Unicode</CharacterSet>
+    <LinkControlFlowGuard>true</LinkControlFlowGuard>
   </PropertyGroup>
   <Import Project="$(VCTargetsPath)\Microsoft.Cpp.props" />
   <ImportGroup Label="ExtensionSettings">
@@ -155,6 +157,7 @@
       <LanguageStandard>stdcpp17</LanguageStandard>
       <MultiProcessorCompilation>true</MultiProcessorCompilation>
       <AdditionalIncludeDirectories>$(LIB_INCLUDES);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
+      <ControlFlowGuard>Guard</ControlFlowGuard>
     </ClCompile>
     <Link>
       <SubSystem>Windows</SubSystem>
@@ -162,6 +165,8 @@
       <EnableCOMDATFolding>true</EnableCOMDATFolding>
       <OptimizeReferences>true</OptimizeReferences>
       <ModuleDefinitionFile>.\OpenTelemetry.AutoInstrumentation.Native.def</ModuleDefinitionFile>
+      <CETCompat>true</CETCompat>
+      <DynamicBase>true</DynamicBase>
     </Link>
     <PreBuildEvent>
       <Command>IF EXIST "$(SolutionDir)pre-build-events-cpp.bat" CALL "$(SolutionDir)pre-build-events-cpp.bat"  "$(TargetPath)"  "$(TargetFileName)"  "$(TargetDir)"  "$(TargetName)"</Command>
@@ -182,6 +187,7 @@
       <LanguageStandard>stdcpp17</LanguageStandard>
       <MultiProcessorCompilation>true</MultiProcessorCompilation>
       <AdditionalIncludeDirectories>$(LIB_INCLUDES);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
+      <ControlFlowGuard>Guard</ControlFlowGuard>
     </ClCompile>
     <Link>
       <SubSystem>Windows</SubSystem>
@@ -189,6 +195,8 @@
       <EnableCOMDATFolding>true</EnableCOMDATFolding>
       <OptimizeReferences>true</OptimizeReferences>
       <ModuleDefinitionFile>.\OpenTelemetry.AutoInstrumentation.Native.def</ModuleDefinitionFile>
+      <CETCompat>true</CETCompat>
+      <DynamicBase>true</DynamicBase>
     </Link>
     <PreBuildEvent>
       <Command>IF EXIST "$(SolutionDir)pre-build-events-cpp.bat" CALL "$(SolutionDir)pre-build-events-cpp.bat"  "$(TargetPath)"  "$(TargetFileName)"  "$(TargetDir)"  "$(TargetName)"</Command>
diff --git a/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.vcxproj b/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.vcxproj
index 601baa80b7..62a30dcdb5 100644
--- a/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.vcxproj
+++ b/src/OpenTelemetry.AutoInstrumentation.Native/OpenTelemetry.AutoInstrumentation.Native.vcxproj
@@ -47,12 +47,14 @@
     <PlatformToolset>v143</PlatformToolset>
     <WholeProgramOptimization>true</WholeProgramOptimization>
     <CharacterSet>Unicode</CharacterSet>
+    <LinkControlFlowGuard>true</LinkControlFlowGuard>
   </PropertyGroup>
   <PropertyGroup Condition="'$(Configuration)|$(Platform)'=='Release|Win32'" Label="Configuration">
     <ConfigurationType>StaticLibrary</ConfigurationType>
     <UseDebugLibraries>false</UseDebugLibraries>
     <PlatformToolset>v143</PlatformToolset>
     <WholeProgramOptimization>true</WholeProgramOptimization>
+    <LinkControlFlowGuard>true</LinkControlFlowGuard>
     <CharacterSet>Unicode</CharacterSet>
   </PropertyGroup>
   <Import Project="$(VCTargetsPath)\Microsoft.Cpp.props" />
@@ -138,12 +140,15 @@
       <PreprocessorDefinitions>_TARGET_64BIT;BIT64;HOST_64BIT;AMD64;_UNICODE;UNICODE;OTEL_AUTO_VERSION_MAJOR=$(OTEL_AUTO_VERSION_MAJOR);OTEL_AUTO_VERSION_MINOR=$(OTEL_AUTO_VERSION_MINOR);OTEL_AUTO_VERSION_PATCH=$(OTEL_AUTO_VERSION_PATCH);%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <AdditionalIncludeDirectories>$(LIB_INCLUDES);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
       <TreatWarningAsError>true</TreatWarningAsError>
+      <ControlFlowGuard>Guard</ControlFlowGuard>
     </ClCompile>
     <Lib>
       <AdditionalLibraryDirectories>$(LIB_INCLUDES);%(AdditionalLibraryDirectories)</AdditionalLibraryDirectories>
     </Lib>
     <Link>
       <AdditionalLibraryDirectories>$(LIB_INCLUDES);%(AdditionalLibraryDirectories)</AdditionalLibraryDirectories>
+      <CETCompat>true</CETCompat>
+      <DynamicBase>true</DynamicBase>
     </Link>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">
@@ -162,12 +167,15 @@
       <PreprocessorDefinitions>_UNICODE;UNICODE;X86;HOST_X86;OTEL_AUTO_VERSION_MAJOR=$(OTEL_AUTO_VERSION_MAJOR);OTEL_AUTO_VERSION_MINOR=$(OTEL_AUTO_VERSION_MINOR);OTEL_AUTO_VERSION_PATCH=$(OTEL_AUTO_VERSION_PATCH);%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <AdditionalIncludeDirectories>$(LIB_INCLUDES);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
       <TreatWarningAsError>true</TreatWarningAsError>
+      <ControlFlowGuard>Guard</ControlFlowGuard>
     </ClCompile>
     <Lib>
       <AdditionalLibraryDirectories>$(LIB_INCLUDES);%(AdditionalLibraryDirectories)</AdditionalLibraryDirectories>
     </Lib>
     <Link>
       <AdditionalLibraryDirectories>$(LIB_INCLUDES);%(AdditionalLibraryDirectories)</AdditionalLibraryDirectories>
+      <CETCompat>true</CETCompat>
+      <DynamicBase>true</DynamicBase>
     </Link>
   </ItemDefinitionGroup>
   <ItemGroup>