diff --git a/.gitmodules b/.gitmodules
index bd4ed5eb06..00fab9fe28 100644
--- a/.gitmodules
+++ b/.gitmodules
@@ -1,4 +1,4 @@
 [submodule "opentelemetry-proto/src/proto/opentelemetry-proto"]
 	path = opentelemetry-proto/src/proto/opentelemetry-proto
 	url = https://github.com/open-telemetry/opentelemetry-proto
-	branch = tags/v1.0.0
+	branch = tags/v1.5.0
diff --git a/Cargo.toml b/Cargo.toml
index 831961a85d..b19195b09e 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -19,7 +19,6 @@ exclude = ["opentelemetry-prometheus"]
 debug = 1
 
 [workspace.dependencies]
-async-std = "1.13"
 async-trait = "0.1"
 bytes = "1"
 criterion = "0.5"
@@ -42,8 +41,8 @@ serde = { version = "1.0", default-features = false }
 serde_json = "1.0"
 temp-env = "0.3.6"
 thiserror = { version = "2", default-features = false }
-tonic = { version = "0.12.3", default-features = false }
-tonic-build = "0.12"
+tonic = { version = "0.13", default-features = false }
+tonic-build = "0.13"
 tokio = { version = "1", default-features = false }
 tokio-stream = "0.1"
 # Using `tracing 0.1.40` because 0.1.39 (which is yanked) introduces the ability to set event names in macros, 
diff --git a/opentelemetry-otlp/CHANGELOG.md b/opentelemetry-otlp/CHANGELOG.md
index eb319791f1..4ad96907a7 100644
--- a/opentelemetry-otlp/CHANGELOG.md
+++ b/opentelemetry-otlp/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## vNext
 
+- Update `tonic` dependency version to 0.13
+
 ## 0.29.0
 
 Released 2025-Mar-21
diff --git a/opentelemetry-otlp/Cargo.toml b/opentelemetry-otlp/Cargo.toml
index 3f219f4148..12524fd04b 100644
--- a/opentelemetry-otlp/Cargo.toml
+++ b/opentelemetry-otlp/Cargo.toml
@@ -49,7 +49,7 @@ opentelemetry_sdk = { features = ["trace", "rt-tokio", "testing"], path = "../op
 tokio = { workspace = true, features = ["macros", "rt-multi-thread"] }
 futures-util = { workspace = true }
 temp-env = { workspace = true }
-tonic = { workspace = true, features = ["server"] }
+tonic = { workspace = true, features = ["router", "server"] }
 
 [features]
 # telemetry pillars and functions
@@ -67,8 +67,8 @@ default = ["http-proto", "reqwest-blocking-client", "trace", "metrics", "logs",
 grpc-tonic = ["tonic", "prost", "http", "tokio", "opentelemetry-proto/gen-tonic"]
 gzip-tonic = ["tonic/gzip"]
 zstd-tonic = ["tonic/zstd"]
-tls = ["tonic/tls"]
-tls-roots = ["tls", "tonic/tls-roots"]
+tls = ["tonic/tls-ring"]
+tls-roots = ["tls", "tonic/tls-native-roots"]
 tls-webpki-roots = ["tls", "tonic/tls-webpki-roots"]
 
 # http binary
diff --git a/opentelemetry-proto/CHANGELOG.md b/opentelemetry-proto/CHANGELOG.md
index 19e34b137d..fe745ca785 100644
--- a/opentelemetry-proto/CHANGELOG.md
+++ b/opentelemetry-proto/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## vNext
 
+- Update `tonic` dependency version to 0.13
+
 ## 0.29.0
 
 Released 2025-Mar-21
diff --git a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.logs.v1.rs b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.logs.v1.rs
index 84c9a5ca93..8a760a46b4 100644
--- a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.logs.v1.rs
+++ b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.logs.v1.rs
@@ -90,7 +90,7 @@ pub mod logs_service_client {
     }
     impl<T> LogsServiceClient<T>
     where
-        T: tonic::client::GrpcService<tonic::body::BoxBody>,
+        T: tonic::client::GrpcService<tonic::body::Body>,
         T::Error: Into<StdError>,
         T::ResponseBody: Body<Data = Bytes> + std::marker::Send + 'static,
         <T::ResponseBody as Body>::Error: Into<StdError> + std::marker::Send,
@@ -111,13 +111,13 @@ pub mod logs_service_client {
             F: tonic::service::Interceptor,
             T::ResponseBody: Default,
             T: tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
                 Response = http::Response<
-                    <T as tonic::client::GrpcService<tonic::body::BoxBody>>::ResponseBody,
+                    <T as tonic::client::GrpcService<tonic::body::Body>>::ResponseBody,
                 >,
             >,
             <T as tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
             >>::Error: Into<StdError> + std::marker::Send + std::marker::Sync,
         {
             LogsServiceClient::new(InterceptedService::new(inner, interceptor))
@@ -278,7 +278,7 @@ pub mod logs_service_server {
         B: Body + std::marker::Send + 'static,
         B::Error: Into<StdError> + std::marker::Send + 'static,
     {
-        type Response = http::Response<tonic::body::BoxBody>;
+        type Response = http::Response<tonic::body::Body>;
         type Error = std::convert::Infallible;
         type Future = BoxFuture<Self::Response, Self::Error>;
         fn poll_ready(
@@ -336,7 +336,9 @@ pub mod logs_service_server {
                 }
                 _ => {
                     Box::pin(async move {
-                        let mut response = http::Response::new(empty_body());
+                        let mut response = http::Response::new(
+                            tonic::body::Body::default(),
+                        );
                         let headers = response.headers_mut();
                         headers
                             .insert(
diff --git a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.metrics.v1.rs b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.metrics.v1.rs
index 1f6951a60f..e1021eaefe 100644
--- a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.metrics.v1.rs
+++ b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.metrics.v1.rs
@@ -90,7 +90,7 @@ pub mod metrics_service_client {
     }
     impl<T> MetricsServiceClient<T>
     where
-        T: tonic::client::GrpcService<tonic::body::BoxBody>,
+        T: tonic::client::GrpcService<tonic::body::Body>,
         T::Error: Into<StdError>,
         T::ResponseBody: Body<Data = Bytes> + std::marker::Send + 'static,
         <T::ResponseBody as Body>::Error: Into<StdError> + std::marker::Send,
@@ -111,13 +111,13 @@ pub mod metrics_service_client {
             F: tonic::service::Interceptor,
             T::ResponseBody: Default,
             T: tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
                 Response = http::Response<
-                    <T as tonic::client::GrpcService<tonic::body::BoxBody>>::ResponseBody,
+                    <T as tonic::client::GrpcService<tonic::body::Body>>::ResponseBody,
                 >,
             >,
             <T as tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
             >>::Error: Into<StdError> + std::marker::Send + std::marker::Sync,
         {
             MetricsServiceClient::new(InterceptedService::new(inner, interceptor))
@@ -278,7 +278,7 @@ pub mod metrics_service_server {
         B: Body + std::marker::Send + 'static,
         B::Error: Into<StdError> + std::marker::Send + 'static,
     {
-        type Response = http::Response<tonic::body::BoxBody>;
+        type Response = http::Response<tonic::body::Body>;
         type Error = std::convert::Infallible;
         type Future = BoxFuture<Self::Response, Self::Error>;
         fn poll_ready(
@@ -336,7 +336,9 @@ pub mod metrics_service_server {
                 }
                 _ => {
                     Box::pin(async move {
-                        let mut response = http::Response::new(empty_body());
+                        let mut response = http::Response::new(
+                            tonic::body::Body::default(),
+                        );
                         let headers = response.headers_mut();
                         headers
                             .insert(
diff --git a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.trace.v1.rs b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.trace.v1.rs
index bf1238f82e..5cc02d67d1 100644
--- a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.trace.v1.rs
+++ b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.collector.trace.v1.rs
@@ -90,7 +90,7 @@ pub mod trace_service_client {
     }
     impl<T> TraceServiceClient<T>
     where
-        T: tonic::client::GrpcService<tonic::body::BoxBody>,
+        T: tonic::client::GrpcService<tonic::body::Body>,
         T::Error: Into<StdError>,
         T::ResponseBody: Body<Data = Bytes> + std::marker::Send + 'static,
         <T::ResponseBody as Body>::Error: Into<StdError> + std::marker::Send,
@@ -111,13 +111,13 @@ pub mod trace_service_client {
             F: tonic::service::Interceptor,
             T::ResponseBody: Default,
             T: tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
                 Response = http::Response<
-                    <T as tonic::client::GrpcService<tonic::body::BoxBody>>::ResponseBody,
+                    <T as tonic::client::GrpcService<tonic::body::Body>>::ResponseBody,
                 >,
             >,
             <T as tonic::codegen::Service<
-                http::Request<tonic::body::BoxBody>,
+                http::Request<tonic::body::Body>,
             >>::Error: Into<StdError> + std::marker::Send + std::marker::Sync,
         {
             TraceServiceClient::new(InterceptedService::new(inner, interceptor))
@@ -278,7 +278,7 @@ pub mod trace_service_server {
         B: Body + std::marker::Send + 'static,
         B::Error: Into<StdError> + std::marker::Send + 'static,
     {
-        type Response = http::Response<tonic::body::BoxBody>;
+        type Response = http::Response<tonic::body::Body>;
         type Error = std::convert::Infallible;
         type Future = BoxFuture<Self::Response, Self::Error>;
         fn poll_ready(
@@ -336,7 +336,9 @@ pub mod trace_service_server {
                 }
                 _ => {
                     Box::pin(async move {
-                        let mut response = http::Response::new(empty_body());
+                        let mut response = http::Response::new(
+                            tonic::body::Body::default(),
+                        );
                         let headers = response.headers_mut();
                         headers
                             .insert(
diff --git a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.metrics.v1.rs b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.metrics.v1.rs
index fb04bec6cc..ff27798ede 100644
--- a/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.metrics.v1.rs
+++ b/opentelemetry-proto/src/proto/tonic/opentelemetry.proto.metrics.v1.rs
@@ -183,7 +183,7 @@ pub struct Metric {
     #[prost(string, tag = "2")]
     pub description: ::prost::alloc::string::String,
     /// unit in which the metric value is reported. Follows the format
-    /// described by <http://unitsofmeasure.org/ucum.html.>
+    /// described by <https://unitsofmeasure.org/ucum.html.>
     #[prost(string, tag = "3")]
     pub unit: ::prost::alloc::string::String,
     /// Additional metadata attributes that describe the metric. \[Optional\].
@@ -292,7 +292,7 @@ pub struct ExponentialHistogram {
 }
 /// Summary metric data are used to convey quantile summaries,
 /// a Prometheus (see: <https://prometheus.io/docs/concepts/metric_types/#summary>)
-/// and OpenMetrics (see: <https://github.com/OpenObservability/OpenMetrics/blob/4dbf6075567ab43296eed941037c12951faafb92/protos/prometheus.proto#L45>)
+/// and OpenMetrics (see: <https://github.com/prometheus/OpenMetrics/blob/4dbf6075567ab43296eed941037c12951faafb92/protos/prometheus.proto#L45>)
 /// data type. These data points cannot always be merged in a meaningful way.
 /// While they can be useful in some applications, histogram data points are
 /// recommended for new applications.
@@ -448,7 +448,9 @@ pub struct HistogramDataPoint {
     /// The sum of the bucket_counts must equal the value in the count field.
     ///
     /// The number of elements in bucket_counts array must be by one greater than
-    /// the number of elements in explicit_bounds array.
+    /// the number of elements in explicit_bounds array. The exception to this rule
+    /// is when the length of bucket_counts is 0, then the length of explicit_bounds
+    /// must also be 0.
     #[prost(fixed64, repeated, tag = "6")]
     pub bucket_counts: ::prost::alloc::vec::Vec<u64>,
     /// explicit_bounds specifies buckets with explicitly defined bounds for values.
@@ -464,6 +466,9 @@ pub struct HistogramDataPoint {
     /// Histogram buckets are inclusive of their upper boundary, except the last
     /// bucket where the boundary is at infinity. This format is intentionally
     /// compatible with the OpenMetrics histogram definition.
+    ///
+    /// If bucket_counts length is 0 then explicit_bounds length must also be 0,
+    /// otherwise the data point is invalid.
     #[prost(double, repeated, tag = "7")]
     pub explicit_bounds: ::prost::alloc::vec::Vec<f64>,
     /// (Optional) List of exemplars collected from