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ClinicalTrials.gov

Search 400,000+ clinical trials. Find active studies by condition, intervention, phase, recruitment status, and more.

Key Tools

ctg_search_studies — Search trials with filters

{
  "name": "ctg_search_studies",
  "arguments": {
    "condition": "myasthenia gravis",
    "intervention": "immunoglobulin",
    "recruitment_status": "RECRUITING",
    "study_type": "INTERVENTIONAL",
    "phase": "PHASE2",
    "max_results": 20
  }
}

Arguments:

  • condition (str): Disease/condition name (auto-mapped to MeSH)
  • intervention (str, optional): Drug/procedure/behavioral intervention
  • recruitment_status (str, optional): RECRUITING, ACTIVE_NOT_RECRUITING, ENROLLING_BY_INVITATION, NOT_YET_RECRUITING, CLOSED_TO_ACCRUAL, CLOSED_TO_ACCRUAL_AND_INTERVENTION, TEMPORARILY_CLOSED_FOR_RECRUITMENT, WITHDRAWN, SUSPENDED, TERMINATED, COMPLETED
  • study_type (str, optional): INTERVENTIONAL, OBSERVATIONAL, EXPANDED_ACCESS
  • phase (str, optional): PHASE1, PHASE2, PHASE3, PHASE4, EARLY_PHASE1
  • max_results (int, default 20): Trials to return

Returns: Array of trials with NCT ID, title, status, recruitment info, locations

ctg_get_study — Get trial details

{
  "name": "ctg_get_study",
  "arguments": {
    "nct_id": "NCT05123456"
  }
}

Arguments:

  • nct_id (str): Trial NCT identifier (e.g., NCT05123456)

Returns: Full trial metadata: description, eligibility, locations, contacts, outcomes, status

ctg_search_by_condition — Search by disease only

{
  "name": "ctg_search_by_condition",
  "arguments": {
    "condition": "multiple sclerosis",
    "max_results": 30
  }
}

Returns: All trials for given condition (any status/phase)

ctg_search_by_intervention — Search by drug/intervention

{
  "name": "ctg_search_by_intervention",
  "arguments": {
    "intervention": "monoclonal antibody",
    "condition": "myasthenia gravis"
  }
}

Returns: Trials using specific intervention (optionally filtered by condition)

ctg_get_study_metadata — Get available fields

{
  "name": "ctg_get_study_metadata",
  "arguments": {}
}

Returns: Complete list of searchable/filterable fields for advanced queries

Use Cases

Find Active Trials for Disease

{
  "name": "ctg_search_studies",
  "arguments": {
    "condition": "myasthenia gravis",
    "recruitment_status": "RECRUITING",
    "max_results": 20
  }
}

Find Trials by Drug

{
  "name": "ctg_search_by_intervention",
  "arguments": {
    "intervention": "eculizumab",
    "max_results": 15
  }
}

Find Trials by Phase (Phase 3 + Phase 4 only)

{
  "name": "ctg_search_studies",
  "arguments": {
    "condition": "primary progressive multiple sclerosis",
    "phase": "PHASE3",
    "recruitment_status": "RECRUITING",
    "max_results": 10
  }
}

Get Trial Details

{
  "name": "ctg_get_study",
  "arguments": {
    "nct_id": "NCT05123456"
  }
}

This returns:

  • Full description and rationale
  • Inclusion/exclusion criteria
  • Primary and secondary outcomes
  • Contact information
  • Study locations
  • Funding source
  • Current enrollment

Find Observational Studies (Non-Interventional)

{
  "name": "ctg_search_studies",
  "arguments": {
    "condition": "myasthenia gravis",
    "study_type": "OBSERVATIONAL",
    "max_results": 20
  }
}

Workflow: Trial Landscape Analysis

  1. Find active trials for your condition
  2. Filter by phase (Phase 2 vs 3 vs 4)
  3. Filter by recruitment status (actively recruiting?)
  4. Check inclusion/exclusion criteria (what populations?)
  5. Identify gaps (what's NOT being studied?)
  6. Contact investigators (trial contacts in metadata)

Data Fields

Available fields for filtering:

  • condition
  • intervention (drug, procedure, behavioral, dietary, etc.)
  • recruitment_status
  • study_type (interventional, observational, expanded access)
  • phase (Phase 1, 2, 3, 4)
  • age (min/max eligible age)
  • gender (all, female, male)
  • accepts_healthy_volunteers (true/false)
  • keyword (custom keywords)
  • funding_source (NIH, industry, university, etc.)
  • study_results (has results posted?)

Notes

  • Coverage: Registered trials (global, including outside US)
  • Registration requirement: FDA mandates registration for investigational drugs
  • Results: ~60% of trials post results (optional, becoming more common)
  • Updates: Trials updated in real-time as status changes
  • Locations: Multi-center trials list all participating centers

Rate Limits

  • No API key required
  • Public endpoint
  • Results cached (30-day TTL)

Examples

Example 1: Find myasthenia gravis trials that are actively recruiting

{
  "method": "tools/call",
  "params": {
    "name": "ctg_search_studies",
    "arguments": {
      "condition": "myasthenia gravis",
      "recruitment_status": "RECRUITING",
      "max_results": 20
    }
  }
}

Example 2: Find complement inhibitor trials in any autoimmune disease

{
  "method": "tools/call",
  "params": {
    "name": "ctg_search_by_intervention",
    "arguments": {
      "intervention": "complement inhibitor",
      "max_results": 30
    }
  }
}

Example 3: Get full details for a specific trial

{
  "method": "tools/call",
  "params": {
    "name": "ctg_get_study",
    "arguments": {
      "nct_id": "NCT05123456"
    }
  }
}

Example 4: Find Phase 3 trials for primary progressive MS

{
  "method": "tools/call",
  "params": {
    "name": "ctg_search_studies",
    "arguments": {
      "condition": "primary progressive multiple sclerosis",
      "phase": "PHASE3",
      "recruitment_status": "RECRUITING",
      "max_results": 10
    }
  }
}