singleGeneDeletion not results

[AgustinPardo]

Hello,

I am trying to use "singleGeneDeletion" function but i have some problems with no results.

This is my model:

Then I run:
[grRatio, grRateKO, grRateWT, hasEffect, delRxns, fluxSolution] = singleGeneDeletion(iEK1011)

The "grRatio" is a vector full of 1. That means that it doesn't have an effect on the deletion. Also "grRateKO" has the same growth as the non-deletion model.

Knocking reactions instead of genes, using "singleRxnDeletion" I have the expected growth decrease and up to 0, so this function is working.

I think that the problem is that is not taking into account the "gene name" linkage to reactions. Does anyone know what may be happening and how to solve it?

• Tried to solve the issue on my own
• Retried to run my code with the latest version of The COBRA Toolbox
• Checked that a similar issue has not already been opened

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[rakshitjgd0]

Same issue with any Model I use #1669

[karabekmez]

The same issue with the model iAF1260.