diff --git a/constraints.txt b/constraints.txt
index 30d555b8cbe..e8dc3cbce54 100644
--- a/constraints.txt
+++ b/constraints.txt
@@ -7,7 +7,7 @@ torchvision==0.21.0
 
 # ONNX
 onnx==1.17.0
-onnxruntime==1.19.2
+onnxruntime==1.21.0
 
 # TensorFlow
 tensorflow==2.15.1
diff --git a/examples/post_training_quantization/onnx/mobilenet_v2/requirements.txt b/examples/post_training_quantization/onnx/mobilenet_v2/requirements.txt
index d921b24de8d..cf5f8102200 100644
--- a/examples/post_training_quantization/onnx/mobilenet_v2/requirements.txt
+++ b/examples/post_training_quantization/onnx/mobilenet_v2/requirements.txt
@@ -3,6 +3,6 @@ tqdm
 scikit-learn
 fastdownload
 onnx==1.17.0
-onnxruntime==1.19.2
+onnxruntime==1.21.0
 openvino==2025.1
 numpy<2
diff --git a/examples/post_training_quantization/onnx/yolov8_quantize_with_accuracy_control/requirements.txt b/examples/post_training_quantization/onnx/yolov8_quantize_with_accuracy_control/requirements.txt
index ab3be4f9526..5bbe562686d 100644
--- a/examples/post_training_quantization/onnx/yolov8_quantize_with_accuracy_control/requirements.txt
+++ b/examples/post_training_quantization/onnx/yolov8_quantize_with_accuracy_control/requirements.txt
@@ -1,4 +1,4 @@
 ultralytics==8.3.22
 onnx==1.17.0
-onnxruntime==1.19.2
+onnxruntime==1.21.0
 openvino==2025.1