diff --git a/.changeset/afraid-monkeys-unite.md b/.changeset/afraid-monkeys-unite.md
new file mode 100644
index 0000000000..3f3b8dfc5d
--- /dev/null
+++ b/.changeset/afraid-monkeys-unite.md
@@ -0,0 +1,5 @@
+---
+'@openproject/primer-view-components': minor
+---
+
+Support dynamic labels for SelectPanel multiple select variant
diff --git a/.playwright/screenshots/snapshots.test.ts-snapshots/primer/open_project/filterable_tree_view/custom_segmented_control/dark_high_contrast.png b/.playwright/screenshots/snapshots.test.ts-snapshots/primer/open_project/filterable_tree_view/custom_segmented_control/dark_high_contrast.png
index 3ad3aa47b8..6cd8569021 100644
Binary files a/.playwright/screenshots/snapshots.test.ts-snapshots/primer/open_project/filterable_tree_view/custom_segmented_control/dark_high_contrast.png and b/.playwright/screenshots/snapshots.test.ts-snapshots/primer/open_project/filterable_tree_view/custom_segmented_control/dark_high_contrast.png differ
diff --git a/app/components/primer/alpha/select_panel_element.ts b/app/components/primer/alpha/select_panel_element.ts
index ae7d8264fa..556d834708 100644
--- a/app/components/primer/alpha/select_panel_element.ts
+++ b/app/components/primer/alpha/select_panel_element.ts
@@ -916,6 +916,8 @@ export class SelectPanelElement extends HTMLElement {
       } else {
         this.#removeSelectedItem(item)
       }
+
+      this.#setDynamicLabel()
     }
 
     this.#updateInput()
@@ -952,8 +954,15 @@ export class SelectPanelElement extends HTMLElement {
     const invokerLabel = this.invokerLabel
     if (!invokerLabel) return
     this.#originalLabel ||= invokerLabel.textContent || ''
-    const itemLabel =
-      this.querySelector(`[${this.ariaSelectionType}=true] .ActionListItem-label`)?.textContent || this.#originalLabel
+    let itemLabel: string | undefined
+    if (this.selectVariant === 'single') {
+      itemLabel = this.querySelector(`[${this.ariaSelectionType}=true] .ActionListItem-label`)?.textContent
+    } else if (this.selectVariant === 'multiple') {
+      itemLabel = Array.from(this.querySelectorAll(`[${this.ariaSelectionType}=true] .ActionListItem-label`))
+        .map(label => label.textContent?.trim() ?? '')
+        .join(', ')
+    }
+    itemLabel ||= this.#originalLabel
     if (itemLabel) {
       const prefixSpan = document.createElement('span')
       prefixSpan.classList.add('color-fg-muted')
diff --git a/previews/primer/alpha/select_panel_preview.rb b/previews/primer/alpha/select_panel_preview.rb
index 3ed0a539ed..d14b059018 100644
--- a/previews/primer/alpha/select_panel_preview.rb
+++ b/previews/primer/alpha/select_panel_preview.rb
@@ -144,15 +144,25 @@ def multiselect(open_on_load: false)
       # @label With dynamic label
       #
       # @param open_on_load toggle
-      def with_dynamic_label(open_on_load: false)
-        render_with_template(locals: { open_on_load: open_on_load })
+      # @param select_variant [Symbol] select [single, multiple]
+      def with_dynamic_label(open_on_load: false, select_variant: :single)
+        render_with_template(locals: {
+          open_on_load: open_on_load,
+          # .to_sym workaround for https://github.com/lookbook-hq/lookbook/issues/640
+          select_variant: select_variant.to_sym
+        })
       end
 
       # @label With dynamic label and aria prefix
       #
       # @param open_on_load toggle
-      def with_dynamic_label_and_aria_prefix(open_on_load: false)
-        render_with_template(locals: { open_on_load: open_on_load })
+      # @param select_variant [Symbol] select [single, multiple]
+      def with_dynamic_label_and_aria_prefix(open_on_load: false, select_variant: :single)
+        render_with_template(locals: {
+          open_on_load: open_on_load,
+          # .to_sym workaround for https://github.com/lookbook-hq/lookbook/issues/640
+          select_variant: select_variant.to_sym
+        })
       end
 
       # @!endgroup
diff --git a/previews/primer/alpha/select_panel_preview/with_dynamic_label.html.erb b/previews/primer/alpha/select_panel_preview/with_dynamic_label.html.erb
index d8010aa017..269b5bd804 100644
--- a/previews/primer/alpha/select_panel_preview/with_dynamic_label.html.erb
+++ b/previews/primer/alpha/select_panel_preview/with_dynamic_label.html.erb
@@ -4,7 +4,7 @@
   data: { interaction_subject: subject_id },
   id: "with_avatar_items",
   title: "Select users",
-  select_variant: :single,
+  select_variant: select_variant,
   fetch_strategy: :local,
   dynamic_label: true,
   dynamic_label_prefix: "Item",
diff --git a/previews/primer/alpha/select_panel_preview/with_dynamic_label_and_aria_prefix.html.erb b/previews/primer/alpha/select_panel_preview/with_dynamic_label_and_aria_prefix.html.erb
index 792f4bf7f3..bbea0676bf 100644
--- a/previews/primer/alpha/select_panel_preview/with_dynamic_label_and_aria_prefix.html.erb
+++ b/previews/primer/alpha/select_panel_preview/with_dynamic_label_and_aria_prefix.html.erb
@@ -4,7 +4,7 @@
   data: { interaction_subject: subject_id },
   id: "with_avatar_items",
   title: "Select users",
-  select_variant: :single,
+  select_variant: select_variant,
   fetch_strategy: :local,
   dynamic_label: true,
   dynamic_label_prefix: "Item",
diff --git a/test/system/alpha/select_panel_test.rb b/test/system/alpha/select_panel_test.rb
index c48cee706a..a2b9b2b1d4 100644
--- a/test/system/alpha/select_panel_test.rb
+++ b/test/system/alpha/select_panel_test.rb
@@ -737,6 +737,56 @@ def test_banner_scheme_is_passed_to_banner_component
       assert_selector "[data-target='select-panel.bannerErrorElement'] .Banner--warning", text: "Sorry, something went wrong"
     end
 
+    def test_dynamic_label_for_single_select_variant
+      visit_preview(:with_dynamic_label, select_variant: :single)
+
+      click_on_invoker_button
+
+      assert_selector "select-panel button[aria-controls]", exact_text: "Item: Choose item"
+
+      click_on_second_item
+
+      assert_selector "select-panel button[aria-controls]", exact_text: "Item: Item 2"
+    end
+
+    def test_dynamic_label_for_multiple_select_variant
+      visit_preview(:with_dynamic_label, select_variant: :multiple)
+
+      click_on_invoker_button
+
+      assert_selector "select-panel button[aria-controls]", exact_text: "Item: Choose item"
+
+      click_on_second_item
+      click_on_third_item
+
+      assert_selector "select-panel button[aria-controls]", exact_text: "Item: Item 2, Item 3"
+    end
+
+    def test_dynamic_label_and_aria_prefix_for_single_select_variant
+      visit_preview(:with_dynamic_label_and_aria_prefix, select_variant: :single)
+
+      click_on_invoker_button
+
+      assert_selector "select-panel button[aria-controls][aria-label='Your item: Choose item']"
+
+      click_on_second_item
+
+      assert_selector "select-panel button[aria-controls][aria-label='Your item: Item 2']"
+    end
+
+    def test_dynamic_label_and_aria_prefix_for_multiple_select_variant
+      visit_preview(:with_dynamic_label_and_aria_prefix, select_variant: :multiple)
+
+      click_on_invoker_button
+
+      assert_selector "select-panel button[aria-controls][aria-label='Your item: Choose item']"
+
+      click_on_second_item
+      click_on_third_item
+
+      assert_selector "select-panel button[aria-controls][aria-label='Your item: Item 2, Item 3']"
+    end
+
     ########## JAVASCRIPT API TESTS ############
 
     def test_disable_item_via_js_api