Enhancement: Minor changes to aNCA Manual

[jimrothstein]

Description

First sentence under Section 3.1 Data Imputation Rules may be unclear to new user.
Make minor changes to increase clarity.

3.1 Data Imputation Rules {#data-imputation-rules}

The imputation actions are specified exclusively for parameters that are not exclusively calculated based on observed concentrations (e.g., Cmax, Tmax, AUClast, etc.) but also for parameters that require extrapolation to infinity (e.g., AUCinf) or parameters that are calculated based on the terminal slope (e.g., half-life, clearance, volume).

Initial Suggestion

Observed parameters based on concentration are never imputed. (Example: cmax, tmax, half.life. For complete list see: xxxx)

However, parameters that depend on AUC or AUMC, including those requiring extrapolation to infinity, do get imputation. (Example: AUCinf, all parameters beginning with auc and aumc. For complete list see: xxxx)

Double check and reference

• T/F "observed result" means ??? (Based solely on concentration and time, not AUC (exposure) )
• Example: half.life is a calculation solely based on measured concentration, so never imputed (see https://humanpred.github.io/pknca/articles/v06-half-life-calculation.html)

Defintion of Done

Not sure yet. Clarity important, but how much detail is beneficial?

[AngelaManginelli]

Hi all,
I agree with this discussion, that the current formulation is not clear (I had to read the sentence a few times ;-) )
I like the suggestion on how to re-formulate proposed by @jimrothstein .
For me a complete list of all parameters that can / cannot be imputed would be useful and more clear. I know it is quite detailed but my understanding is that the manual should provide enough information to a developer to understand how the method and therefore the app works.

[jimrothstein]

@AngelaManginelli

For me a complete list of all parameters that can / cannot be imputed would be useful and more clear. I know it is quite detailed ... developer to understand how the method and therefore the app works.

😄

This is from an LLM .... so do not accept as TRUE.

811_aNCA_imputation_rules.md