Description
metadata_nca_parameters.csv has incorrect PPTESTCD codes and PPTEST labels for three CAVG interval parameters and the end-of-infusion concentration parameter.
The CAVG codes are truncated — built from CAVGIN + suffix instead of CAVGINT + suffix (missing the T from the base code CAVGINT). The CEOI code is a non-descriptive abbreviation that should follow CDISC-style naming.
Current vs Expected
| PKNCA |
Current PPTESTCD |
Correct PPTESTCD |
Current PPTEST |
Correct PPTEST |
cav.int.all |
CAVGINA |
CAVGINTA |
Cavg All |
Average Conc Interval (based on AUCall) |
cav.int.inf.obs |
CAVGINO |
CAVGINTO |
Cavg Infinity Obs |
Average Conc Interval (based on AUCinf,obs) |
cav.int.inf.pred |
CAVGINP |
CAVGINTP |
Cavg Infinity Pred |
Average Conc Interval (based on AUCinf,pred) |
ceoi |
CEOI |
CONCEINF |
Ceoi |
Concentration at End Infusion |
The base parameter cav.int.last → CAVGINT / "Average Conc from T1 to T2" is correct.
These are non-CDISC parameters (is_cdisc_sure = FALSE), so the naming follows internal convention.
Files to update
data-raw/metadata_nca_parameters.csv — fix PPTESTCD, PPTEST, and input_names columns
data/metadata_nca_parameters.rda — regenerate via Rscript data-raw/metadata_nca_parameters.R
Definition of Done
Description
metadata_nca_parameters.csvhas incorrect PPTESTCD codes and PPTEST labels for three CAVG interval parameters and the end-of-infusion concentration parameter.The CAVG codes are truncated — built from
CAVGIN+ suffix instead ofCAVGINT+ suffix (missing theTfrom the base codeCAVGINT). The CEOI code is a non-descriptive abbreviation that should follow CDISC-style naming.Current vs Expected
cav.int.allcav.int.inf.obscav.int.inf.predceoiThe base parameter
cav.int.last→CAVGINT/ "Average Conc from T1 to T2" is correct.These are non-CDISC parameters (
is_cdisc_sure = FALSE), so the naming follows internal convention.Files to update
data-raw/metadata_nca_parameters.csv— fix PPTESTCD, PPTEST, and input_names columnsdata/metadata_nca_parameters.rda— regenerate viaRscript data-raw/metadata_nca_parameters.RDefinition of Done
input_namescolumn updated to match new PPTESTCD and PPTEST.rdafile regenerated