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Bug: incorrect PPTESTCD and PPTEST for CAVG interval parameters #1236

@Gero1999

Description

@Gero1999

Description

metadata_nca_parameters.csv has incorrect PPTESTCD codes and PPTEST labels for three CAVG interval parameters and the end-of-infusion concentration parameter.

The CAVG codes are truncated — built from CAVGIN + suffix instead of CAVGINT + suffix (missing the T from the base code CAVGINT). The CEOI code is a non-descriptive abbreviation that should follow CDISC-style naming.

Current vs Expected

PKNCA Current PPTESTCD Correct PPTESTCD Current PPTEST Correct PPTEST
cav.int.all CAVGINA CAVGINTA Cavg All Average Conc Interval (based on AUCall)
cav.int.inf.obs CAVGINO CAVGINTO Cavg Infinity Obs Average Conc Interval (based on AUCinf,obs)
cav.int.inf.pred CAVGINP CAVGINTP Cavg Infinity Pred Average Conc Interval (based on AUCinf,pred)
ceoi CEOI CONCEINF Ceoi Concentration at End Infusion

The base parameter cav.int.lastCAVGINT / "Average Conc from T1 to T2" is correct.

These are non-CDISC parameters (is_cdisc_sure = FALSE), so the naming follows internal convention.

Files to update

  • data-raw/metadata_nca_parameters.csv — fix PPTESTCD, PPTEST, and input_names columns
  • data/metadata_nca_parameters.rda — regenerate via Rscript data-raw/metadata_nca_parameters.R

Definition of Done

  • PPTESTCD codes corrected to CAVGINTA, CAVGINTO, CAVGINTP, CONCEINF
  • PPTEST values updated
  • input_names column updated to match new PPTESTCD and PPTEST
  • .rda file regenerated

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