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#74 udpate wording
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adam/adae.qmd

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# Select ADSL Variables {#adslvars}
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Some variables from the `ADSL` dataset required for the derivations are merged into the `AE` domain using the `admiral::derive_vars_merged()` function. Find other `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). The rest of the relevant `ADSL` variables will be added later.
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Some variables from the `ADSL` dataset required for the derivations are merged into the `AE` domain using the `admiral::derive_vars_merged()` function. Find other `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). The rest of the relevant `ADSL` variables will be added later.
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```{r}
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# Select required ADSL variables

adam/adpc.qmd

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## First Load Packages
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find other `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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The source SDTM data will come from the CDISC pilot study data stored in `{pharmaversesdtm}`.
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adam/adppk.qmd

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## First Load Packages
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find other `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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The source SDTM data will come from the CDISC pilot study data stored in `{pharmaversesdtm}`.
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adam/adrs.qmd

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# Introduction
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The Response Analysis Dataset (`ADRS`) is an essential part of oncology clinical trials for monitoring disease response and progression. This article describes how to create an `ADRS` ADaM dataset, focusing on common oncology endpoint parameters based on RECIST v1.1 criteria. The primary response values include `CR` (Complete Response), `PR` (Partial Response), `SD` (Stable Disease), `NON-CR/NON-PD` (Non-CR/Non-PD), `PD` (Progressive Disease), and `NE` (Not Evaluable). See `{admiral}` and `{admiralonco}` for mor information. Find other `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>)
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The Response Analysis Dataset (`ADRS`) is an essential part of oncology clinical trials for monitoring disease response and progression. This article describes how to create an `ADRS` ADaM dataset, focusing on common oncology endpoint parameters based on RECIST v1.1 criteria. The primary response values include `CR` (Complete Response), `PR` (Partial Response), `SD` (Stable Disease), `NON-CR/NON-PD` (Non-CR/Non-PD), `PD` (Progressive Disease), and `NE` (Not Evaluable). See `{admiral}` and `{admiralonco}` for mor information. Find other `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>)
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This guide uses key pharmaverse packages along with tidyverse components to demonstrate the step-by-step process, ensuring the inclusion of metadata, validation, and exporting to a compliant SAS transport file (XPT).
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adam/adsl.qmd

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- [`{metacore}`](https://atorus-research.github.io/metacore/): provides harmonized metadata/specifications object.
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- [`{metatools}`](https://pharmaverse.github.io/metatools/): uses the provided metadata to build/enhance and check the dataset.
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- [`{admiral}`](https://pharmaverse.github.io/admiral/index.html): provides the ADaM derivations. (Find variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>))
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- [`{admiral}`](https://pharmaverse.github.io/admiral/index.html): provides the ADaM derivations. (Find functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>))
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- [`{xportr}`](https://atorus-research.github.io/xportr/): delivers the SAS transport file (XPT) and eSub checks.
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It is important to understand `{metacore}` objects by reading through the above linked package site, as these are fundamental to being able to use `{metatools}` and `{xportr}`.

adam/adtte.qmd

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# Define Event and Censoring Sources
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We define event and censoring sources using the `admiral::event_source()` and `admiral::censor_source()` functions. This forms the basis for calculating time-to-event endpoints. Find other `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>).
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We define event and censoring sources using the `admiral::event_source()` and `admiral::censor_source()` functions. This forms the basis for calculating time-to-event endpoints. Find other `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>).
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```{r}
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# Define event and censoring sources

adam/advs.qmd

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# Load Data and Required pharmaverse Packages {#loaddata}
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find `{admiral}` variables and functions by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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First we will load the packages required for our project. We will use `{admiral}` for the creation of analysis data. `{admiral}` requires `{dplyr}`, `{lubridate}` and `{stringr}`. Find `{admiral}` functions and related variables by searching [admiraldiscovery](<https://pharmaverse.github.io/admiraldiscovery/articles/reactable.html>). We will use `{metacore}` and `{metatools}` to store and manipulate metadata from our specifications. We will use `{xportr}` to perform checks on the final data and export to a transport file.
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Then we will load our input data.
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