If you'll try to run curl with --http2 flag with curl shipped with macOS by default (as of macOS 10.12) you'll get the following error:
curl -I --http2 https://http2.akamai.com/
curl: (1) Unsupported protocolTo fix that you can reinstall curl using brew with --with-nghttp2 flag and replace the standard curl with newly installed:
brew install curl --with-nghttp2
brew link curl --forceand after you restart your terminal:
curl -I --http2 https://http2.akamai.com/
HTTP/2 200
server: Apache
...