diff --git a/Zend/Zend.m4 b/Zend/Zend.m4
index 72bc116f7edb..fd8eee17f23f 100644
--- a/Zend/Zend.m4
+++ b/Zend/Zend.m4
@@ -330,6 +330,24 @@ AS_VAR_IF([php_cv_have_global_register_vars], [yes],
 ])
 AC_MSG_CHECKING([whether to enable global register variables support])
 AC_MSG_RESULT([$ZEND_GCC_GLOBAL_REGS])
+
+dnl GCC doesn't propagate -ffixed-* from LTO objects. Reserve the VM registers
+dnl before LTO code gen to avoid "global register variable follows a function definition"
+AS_VAR_IF([ZEND_GCC_GLOBAL_REGS], [yes], [
+  zend_lto=no
+  for zend_flag in $CC $CFLAGS $LDFLAGS; do
+    AS_CASE([$zend_flag], [-flto|-flto=*], [zend_lto=yes], [-fno-lto], [zend_lto=no])
+  done
+  AS_VAR_IF([zend_lto], [yes], [
+    AS_CASE([$host_cpu],
+      [x86_64*|amd64*], [AS_VAR_APPEND([LDFLAGS], [" -ffixed-r14 -ffixed-r15"])],
+      [x86*|amd*|i?86*|pentium], [AS_VAR_APPEND([LDFLAGS], [" -ffixed-esi -ffixed-edi"])],
+      [aarch64*|arm64*], [AS_VAR_APPEND([LDFLAGS], [" -ffixed-x27 -ffixed-x28"])],
+      [ppc64*|powerpc64*], [AS_VAR_APPEND([LDFLAGS], [" -ffixed-r14 -ffixed-r15"])],
+      [riscv64*], [AS_VAR_APPEND([LDFLAGS], [" -ffixed-x18 -ffixed-x19"])],
+      [AC_MSG_ERROR([Cannot reserve VM registers for LTO, disable LTO or use --disable-gcc-global-regs])])
+  ])
+])
 ])
 
 dnl
diff --git a/build/ltmain.sh b/build/ltmain.sh
index 3c00e7915707..7cfa084920fc 100755
--- a/build/ltmain.sh
+++ b/build/ltmain.sh
@@ -1689,6 +1689,8 @@ EOF
       # -p, -pg, --coverage, -fprofile-* pass through profiling flag for GCC
       # -F/path gives path to uninstalled frameworks, gcc on darwin
       # @file GCC response files
+      # -ffixed-*, -fno-lto GCC LTO register reservations and cancellation
+      -ffixed-*|-fno-lto| \
       -64|-mips[0-9]|-r[0-9][0-9]*|-xarch=*|-xtarget=*|+DA*|+DD*|-q*|-m*| \
       -t[45]*|-txscale*|-p|-pg|--coverage|-fprofile-*|-F*|@*)