diff --git a/index.js b/index.js
index 30ac154..e50bb7f 100644
--- a/index.js
+++ b/index.js
@@ -1,3 +1,20 @@
+/** Check if node is a template literal with no expressions (e.g., `foo`) */
+function isConstantTemplateLiteral(t, node) {
+  return (
+    t.isTemplateLiteral(node) &&
+    node.expressions.length === 0 &&
+    node.quasis.length === 1
+  );
+}
+
+/** Create a template literal node with no expressions (e.g., `foo`) */
+function constantTemplateLiteral(t, value) {
+  return t.templateLiteral(
+    [t.templateElement({ raw: value, cooked: value }, true)],
+    []
+  );
+}
+
 module.exports = function ({ types: t }, options = {}) {
   const rename = options.rename || {};
 
@@ -78,6 +95,39 @@ module.exports = function ({ types: t }, options = {}) {
           path.skip();
         },
       },
+      BinaryExpression: {
+        exit(path) {
+          const node = path.node;
+          if (node.operator !== "in") {
+            return;
+          }
+
+          let oldName;
+          let isTemplateLiteral = false;
+
+          if (t.isStringLiteral(node.left)) {
+            oldName = node.left.value;
+          } else if (isConstantTemplateLiteral(t, node.left)) {
+            oldName = node.left.quasis[0].value.cooked;
+            isTemplateLiteral = true;
+          } else {
+            return;
+          }
+
+          const newName = nameMap.get(oldName);
+          if (newName === undefined) {
+            return;
+          }
+
+          const newNode = isTemplateLiteral
+            ? constantTemplateLiteral(t, newName)
+            : t.stringLiteral(newName);
+
+          const replacedNode = t.binaryExpression("in", newNode, node.right);
+          path.replaceWith(replacedNode);
+          path.skip();
+        },
+      },
     },
   };
 };
diff --git a/test/index.test.js b/test/index.test.js
index ee59b57..caa0d7a 100644
--- a/test/index.test.js
+++ b/test/index.test.js
@@ -194,4 +194,59 @@ describe("babel-plugin-transform-rename-properties", () => {
       });
     });
   });
+
+  describe("for `in` operator", () => {
+    it("renames string literal property", () => {
+      compare("'foo' in obj", "'__FOO__' in obj", {
+        rename: { foo: "__FOO__" },
+      });
+    });
+    it("does not rename non-literal property", () => {
+      compare("prop in obj", "prop in obj", {
+        rename: { prop: "__PROP__" },
+      });
+
+      compare("('prop' + '1') in obj", "('prop' + '1') in obj", {
+        rename: { prop: "__PROP__" },
+      });
+    });
+    it("does not rename numeric literal property", () => {
+      compare("42 in obj", "42 in obj", {
+        rename: { 42: "__FORTY_TWO__" },
+      });
+    });
+    it("renames multiple `in` expressions", () => {
+      compare(
+        "'foo' in obj && 'bar' in obj",
+        "'__FOO__' in obj && '__BAR__' in obj",
+        {
+          rename: { foo: "__FOO__", bar: "__BAR__" },
+        }
+      );
+    });
+    it("renames `in` when right-hand side contains property access", () => {
+      compare("'foo' in obj.bar", "'__FOO__' in obj.__BAR__", {
+        rename: { foo: "__FOO__", bar: "__BAR__" },
+      });
+    });
+    it("renames constant template literal property", () => {
+      compare("`foo` in obj", "`__FOO__` in obj", {
+        rename: { foo: "__FOO__" },
+      });
+    });
+    it("does not rename non-constant template literal property", () => {
+      compare("`${prop}` in obj", "`${prop}` in obj", {
+        rename: { prop: "__PROP__" },
+      });
+
+      compare("`prop${prop}` in obj", "`prop${prop}` in obj", {
+        rename: { prop: "__PROP__" },
+      });
+    });
+    it("renames nested `in` expressions", () => {
+      compare("'foo' in ('bar' in obj)", "'__FOO__' in ('__BAR__' in obj)", {
+        rename: { foo: "__FOO__", bar: "__BAR__" },
+      });
+    });
+  });
 });