404 Error from Mouse in dc.op.resource Function

[stevenjbark]

Report

April 10, 2026 at 9:12am:

I attempted to use the dc.op.resource() function for MSigDB specifically for organism='mouse'. I received the following error:

msigdb = dc.op.resource('MSigDB', organism='mouse')

HTTPError: 404 Client Error: Not Found for url: https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_mouse_hcop_fifteen_column.txt.gz

Retrieval of information on dc.op.show_resources() and dc.op.show_organisms worked perfectly.

I tried several tests using organism='human' and this worked. I then tested organism='rat' and the same error happened, but this time the human_rat_hcop_fifteen_column.txt.gz was not found. The same occurred with organism='fruitfly' with the human_fruitflay_hcop_fifteen_column.txt.gz not found. I think there is a problem with the EBI FTP site, specifically with the hcop directory, but wanted to bring your attention to this in case there has been a restructuring of this FTP site.

FULL ERROR LOG

HTTPError                                 Traceback (most recent call last)
Cell In[15], line 1
----> 1 msigdb = dc.op.resource('MSigDB', organism='mouse')

File ~/anaconda3/envs/decoupler/lib/python3.11/site-packages/decoupler/op/_resource.py:105, in resource(name, organism, license, verbose)
    103 df = _infer_dtypes(df)
    104 if organism != "human":
--> 105     df = translate(df, columns="genesymbol", target_organism=organism, verbose=verbose)
    106 return df

File ~/anaconda3/envs/decoupler/lib/python3.11/site-packages/decoupler/op/_translate.py:185, in translate(net, columns, target_organism, min_evidence, one_to_many, verbose)
    183 # Process orthologs
    184 url = f"[https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_{target_organism}_hcop_fifteen_column.txt.gz](https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_%7Btarget_organism%7D_hcop_fifteen_column.txt.gz)"
--> 185 map_df = _download(url, verbose=verbose)
    186 map_df = _bytes_to_pandas(map_df, low_memory=False, compression="gzip", sep="\t")
    187 map_df = pd.read_csv(url, sep="\t", low_memory=False)

File ~/anaconda3/envs/decoupler/lib/python3.11/site-packages/decoupler/_download.py:58, in _download(url, verbose, retries, wait_time)
     56 for attempt in range(1, retries + 1):
     57     try:
---> 58         data = _download_chunks(url, verbose=verbose)
     59         break
     60     except requests.exceptions.HTTPError as e:

File ~/anaconda3/envs/decoupler/lib/python3.11/site-packages/decoupler/_download.py:25, in _download_chunks(url, verbose)
     23 headers = {"User-Agent": f"decoupler/{__version__} (https://github.com/scverse/decoupler)"}
     24 with requests.get(url, stream=True, headers=headers) as r:
---> 25     r.raise_for_status()
     26     total = r.headers.get("Content-Length")
     27     total = int(total) if total and total.isdigit() else None

File ~/anaconda3/envs/decoupler/lib/python3.11/site-packages/requests/models.py:1026, in Response.raise_for_status(self)
   1021     http_error_msg = (
   1022         f"{self.status_code} Server Error: {reason} for url: {self.url}"
   1023     )
   1025 if http_error_msg:
-> 1026     raise HTTPError(http_error_msg, response=self)

HTTPError: 404 Client Error: Not Found for url: https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_mouse_hcop_fifteen_column.txt.gz

FULL LIST OF ENVIRONMENT

# Name                    Version                   Build  Channel
_libgcc_mutex             0.1                 conda_forge    conda-forge
_openmp_mutex             4.5                       2_gnu    conda-forge
adjusttext                1.3.0              pyhd8ed1ab_0    conda-forge
anndata                   0.12.1             pyhd8ed1ab_0    conda-forge
anyio                     4.9.0              pyh29332c3_0    conda-forge
argon2-cffi               25.1.0             pyhd8ed1ab_0    conda-forge
argon2-cffi-bindings      21.2.0          py311h9ecbd09_5    conda-forge
arpack                    3.9.1           nompi_hf03ea27_102    conda-forge
array-api-compat          1.12.0             pyhe01879c_0    conda-forge
arrow                     1.3.0              pyhd8ed1ab_1    conda-forge
asttokens                 3.0.0              pyhd8ed1ab_1    conda-forge
async-lru                 2.0.5              pyh29332c3_0    conda-forge
attrs                     25.3.0             pyh71513ae_0    conda-forge
babel                     2.17.0             pyhd8ed1ab_0    conda-forge
bbknn                     1.6.0           py311h6cce608_5    bioconda
beautifulsoup4            4.13.4             pyha770c72_0    conda-forge
bleach                    6.2.0              pyh29332c3_4    conda-forge
bleach-with-css           6.2.0                h82add2a_4    conda-forge
brotli                    1.1.0                hb9d3cd8_3    conda-forge
brotli-bin                1.1.0                hb9d3cd8_3    conda-forge
brotli-python             1.1.0           py311hfdbb021_3    conda-forge
bzip2                     1.0.8                h4bc722e_7    conda-forge
c-ares                    1.34.5               hb9d3cd8_0    conda-forge
ca-certificates           2026.2.25            hbd8a1cb_0    conda-forge
cached-property           1.5.2                hd8ed1ab_1    conda-forge
cached_property           1.5.2              pyha770c72_1    conda-forge
certifi                   2026.2.25          pyhd8ed1ab_0    conda-forge
cffi                      1.17.1          py311hf29c0ef_0    conda-forge
charset-normalizer        3.4.2              pyhd8ed1ab_0    conda-forge
colorama                  0.4.6              pyhd8ed1ab_1    conda-forge
comm                      0.2.2              pyhd8ed1ab_1    conda-forge
contourpy                 1.3.2           py311hd18a35c_0    conda-forge
crc32c                    2.7.1           py311h9ecbd09_1    conda-forge
cuda-version              12.9                 h4f385c5_3    conda-forge
cycler                    0.12.1             pyhd8ed1ab_1    conda-forge
dcor                      0.6                pyhd8ed1ab_1    conda-forge
debugpy                   1.8.15          py311hc665b79_0    conda-forge
decorator                 5.2.1              pyhd8ed1ab_0    conda-forge
decoupler-py              2.1.5              pyhd8ed1ab_0    conda-forge
defusedxml                0.7.1              pyhd8ed1ab_0    conda-forge
deprecated                1.2.18             pyhd8ed1ab_0    conda-forge
docrep                    0.3.2              pyh44b312d_0    conda-forge
donfig                    0.8.1.post1        pyhd8ed1ab_1    conda-forge
et_xmlfile                2.0.0              pyhd8ed1ab_1    conda-forge
exceptiongroup            1.3.0              pyhd8ed1ab_0    conda-forge
executing                 2.2.0              pyhd8ed1ab_0    conda-forge
fonttools                 4.59.0          py311h3778330_0    conda-forge
fqdn                      1.5.1              pyhd8ed1ab_1    conda-forge
freetype                  2.13.3               ha770c72_1    conda-forge
glpk                      5.0                  h445213a_0    conda-forge
gmp                       6.3.0                hac33072_2    conda-forge
h11                       0.16.0             pyhd8ed1ab_0    conda-forge
h2                        4.2.0              pyhd8ed1ab_0    conda-forge
h5py                      3.14.0          nompi_py311h7f87ba5_100    conda-forge
hdf5                      1.14.6          nompi_h6e4c0c1_103    conda-forge
hpack                     4.1.0              pyhd8ed1ab_0    conda-forge
httpcore                  1.0.9              pyh29332c3_0    conda-forge
httpx                     0.28.1             pyhd8ed1ab_0    conda-forge
hyperframe                6.1.0              pyhd8ed1ab_0    conda-forge
icu                       75.1                 he02047a_0    conda-forge
idna                      3.10               pyhd8ed1ab_1    conda-forge
importlib-metadata        8.7.0              pyhe01879c_1    conda-forge
ipykernel                 6.29.5             pyh3099207_0    conda-forge
ipython                   9.4.0              pyhfa0c392_0    conda-forge
ipython_pygments_lexers   1.1.1              pyhd8ed1ab_0    conda-forge
ipywidgets                8.1.7              pyhd8ed1ab_0    conda-forge
isoduration               20.11.0            pyhd8ed1ab_1    conda-forge
jedi                      0.19.2             pyhd8ed1ab_1    conda-forge
jinja2                    3.1.6              pyhd8ed1ab_0    conda-forge
joblib                    1.5.1              pyhd8ed1ab_0    conda-forge
json5                     0.12.0             pyhd8ed1ab_0    conda-forge
jsonpointer               3.0.0           py311h38be061_1    conda-forge
jsonschema                4.25.0             pyhe01879c_0    conda-forge
jsonschema-specifications 2025.4.1           pyh29332c3_0    conda-forge
jsonschema-with-format-nongpl 4.25.0               he01879c_0    conda-forge
jupyter                   1.1.1              pyhd8ed1ab_1    conda-forge
jupyter-lsp               2.2.6              pyhe01879c_0    conda-forge
jupyter_client            8.6.3              pyhd8ed1ab_1    conda-forge
jupyter_console           6.6.3              pyhd8ed1ab_1    conda-forge
jupyter_core              5.8.1              pyh31011fe_0    conda-forge
jupyter_events            0.12.0             pyh29332c3_0    conda-forge
jupyter_server            2.16.0             pyhe01879c_0    conda-forge
jupyter_server_terminals  0.5.3              pyhd8ed1ab_1    conda-forge
jupyterlab                4.4.5              pyhd8ed1ab_0    conda-forge
jupyterlab_pygments       0.3.0              pyhd8ed1ab_2    conda-forge
jupyterlab_server         2.27.3             pyhd8ed1ab_1    conda-forge
jupyterlab_widgets        3.0.15             pyhd8ed1ab_0    conda-forge
keyutils                  1.6.1                h166bdaf_0    conda-forge
kiwisolver                1.4.8           py311hd18a35c_1    conda-forge
krb5                      1.21.3               h659f571_0    conda-forge
lark                      1.2.2              pyhd8ed1ab_1    conda-forge
lcms2                     2.17                 h717163a_0    conda-forge
ld_impl_linux-64          2.44                 h1423503_1    conda-forge
legacy-api-wrap           1.4.1              pyhd8ed1ab_0    conda-forge
legendkit                 0.3.4              pyhd8ed1ab_0    conda-forge
lerc                      4.0.0                h0aef613_1    conda-forge
libaec                    1.1.4                h3f801dc_0    conda-forge
libblas                   3.9.0           32_h59b9bed_openblas    conda-forge
libbrotlicommon           1.1.0                hb9d3cd8_3    conda-forge
libbrotlidec              1.1.0                hb9d3cd8_3    conda-forge
libbrotlienc              1.1.0                hb9d3cd8_3    conda-forge
libcblas                  3.9.0           32_he106b2a_openblas    conda-forge
libcurl                   8.14.1               h332b0f4_0    conda-forge
libdeflate                1.24                 h86f0d12_0    conda-forge
libedit                   3.1.20250104    pl5321h7949ede_0    conda-forge
libev                     4.33                 hd590300_2    conda-forge
libexpat                  2.7.1                hecca717_0    conda-forge
libffi                    3.4.6                h2dba641_1    conda-forge
libfreetype               2.13.3               ha770c72_1    conda-forge
libfreetype6              2.13.3               h48d6fc4_1    conda-forge
libgcc                    15.1.0               h767d61c_3    conda-forge
libgcc-ng                 15.1.0               h69a702a_3    conda-forge
libgfortran               15.1.0               h69a702a_3    conda-forge
libgfortran5              15.1.0               hcea5267_3    conda-forge
libgomp                   15.1.0               h767d61c_3    conda-forge
libhwloc                  2.12.1          default_h3d81e11_1000    conda-forge
libiconv                  1.18                 h4ce23a2_1    conda-forge
libjpeg-turbo             3.1.0                hb9d3cd8_0    conda-forge
liblapack                 3.9.0           32_h7ac8fdf_openblas    conda-forge
liblzma                   5.8.1                hb9d3cd8_2    conda-forge
libnghttp2                1.64.0               h161d5f1_0    conda-forge
libnsl                    2.0.1                hb9d3cd8_1    conda-forge
libopenblas               0.3.30          pthreads_h94d23a6_0    conda-forge
libpng                    1.6.50               h943b412_0    conda-forge
libsodium                 1.0.20               h4ab18f5_0    conda-forge
libsqlite                 3.50.3               hee844dc_1    conda-forge
libssh2                   1.11.1               hcf80075_0    conda-forge
libstdcxx                 15.1.0               h8f9b012_3    conda-forge
libstdcxx-ng              15.1.0               h4852527_3    conda-forge
libtiff                   4.7.0                hf01ce69_5    conda-forge
libuuid                   2.38.1               h0b41bf4_0    conda-forge
libwebp-base              1.6.0                hd42ef1d_0    conda-forge
libxcb                    1.17.0               h8a09558_0    conda-forge
libxcrypt                 4.4.36               hd590300_1    conda-forge
libxgboost                3.0.2           cuda128_hacb7753_0    conda-forge
libxml2                   2.13.8               h4bc477f_0    conda-forge
libzlib                   1.3.1                hb9d3cd8_2    conda-forge
llvmlite                  0.44.0          py311h9c9ff8c_1    conda-forge
markupsafe                3.0.2           py311h2dc5d0c_1    conda-forge
marsilea                  0.5.3              pyhd8ed1ab_0    conda-forge
matplotlib-base           3.10.3          py311h2b939e6_0    conda-forge
matplotlib-inline         0.1.7              pyhd8ed1ab_1    conda-forge
matplotlib-venn           1.1.2              pyhd8ed1ab_0    conda-forge
mistune                   3.1.3              pyh29332c3_0    conda-forge
msgpack-python            1.1.1           py311hd18a35c_0    conda-forge
munkres                   1.1.4              pyhd8ed1ab_1    conda-forge
natsort                   8.4.0              pyh29332c3_1    conda-forge
nbclient                  0.10.2             pyhd8ed1ab_0    conda-forge
nbconvert-core            7.16.6             pyh29332c3_0    conda-forge
nbformat                  5.10.4             pyhd8ed1ab_1    conda-forge
nccl                      2.27.6.1             h49b9d9a_1    conda-forge
ncurses                   6.5                  h2d0b736_3    conda-forge
nest-asyncio              1.6.0              pyhd8ed1ab_1    conda-forge
networkx                  3.5                pyhe01879c_0    conda-forge
notebook                  7.4.4              pyhd8ed1ab_0    conda-forge
notebook-shim             0.2.4              pyhd8ed1ab_1    conda-forge
numba                     0.61.2          py311h9806782_1    conda-forge
numcodecs                 0.16.1          py311h7db5c69_0    conda-forge
numpy                     2.2.6           py311h5d046bc_0    conda-forge
openjpeg                  2.5.3                h5fbd93e_0    conda-forge
openpyxl                  3.1.5           py311h534898f_3    conda-forge
openssl                   3.6.2                h35e630c_0    conda-forge
overrides                 7.7.0              pyhd8ed1ab_1    conda-forge
packaging                 25.0               pyh29332c3_1    conda-forge
pandas                    2.3.1           py311hed34c8f_0    conda-forge
pandocfilters             1.5.0              pyhd8ed1ab_0    conda-forge
parso                     0.8.4              pyhd8ed1ab_1    conda-forge
patsy                     1.0.1              pyhd8ed1ab_1    conda-forge
pexpect                   4.9.0              pyhd8ed1ab_1    conda-forge
pickleshare               0.7.5           pyhd8ed1ab_1004    conda-forge
pillow                    11.3.0          py311h1322bbf_0    conda-forge
pip                       25.1.1             pyh8b19718_0    conda-forge
platformdirs              4.3.8              pyhe01879c_0    conda-forge
prometheus_client         0.22.1             pyhd8ed1ab_0    conda-forge
prompt-toolkit            3.0.51             pyha770c72_0    conda-forge
prompt_toolkit            3.0.51               hd8ed1ab_0    conda-forge
psutil                    7.0.0           py311h9ecbd09_0    conda-forge
pthread-stubs             0.4               hb9d3cd8_1002    conda-forge
ptyprocess                0.7.0              pyhd8ed1ab_1    conda-forge
pure_eval                 0.2.3              pyhd8ed1ab_1    conda-forge
py-xgboost                3.0.2           cuda128_pyhee1328b_0    conda-forge
pycparser                 2.22               pyh29332c3_1    conda-forge
pygments                  2.19.2             pyhd8ed1ab_0    conda-forge
pynndescent               0.5.13             pyhd8ed1ab_1    conda-forge
pyparsing                 3.2.3              pyhd8ed1ab_1    conda-forge
pysocks                   1.7.1              pyha55dd90_7    conda-forge
python                    3.11.13         h9e4cc4f_0_cpython    conda-forge
python-annoy              1.17.3          py311h1ddb823_3    conda-forge
python-dateutil           2.9.0.post0        pyhe01879c_2    conda-forge
python-fastjsonschema     2.21.1             pyhd8ed1ab_0    conda-forge
python-igraph             0.11.9          py311h423b5fc_0    conda-forge
python-json-logger        2.0.7              pyhd8ed1ab_0    conda-forge
python-tzdata             2025.2             pyhd8ed1ab_0    conda-forge
python_abi                3.11                    8_cp311    conda-forge
pytz                      2025.2             pyhd8ed1ab_0    conda-forge
pyyaml                    6.0.2           py311h2dc5d0c_2    conda-forge
pyzmq                     27.0.0          py311h7deb3e3_0    conda-forge
qhull                     2020.2               h434a139_5    conda-forge
readline                  8.2                  h8c095d6_2    conda-forge
referencing               0.36.2             pyh29332c3_0    conda-forge
requests                  2.32.4             pyhd8ed1ab_0    conda-forge
rfc3339-validator         0.1.4              pyhd8ed1ab_1    conda-forge
rfc3986-validator         0.1.1              pyh9f0ad1d_0    conda-forge
rfc3987-syntax            1.1.0              pyhe01879c_1    conda-forge
rpds-py                   0.26.0          py311hdae7d1d_0    conda-forge
scanpy                    1.11.3             pyhd8ed1ab_0    conda-forge
scikit-learn              1.7.1           py311hc3e1efb_0    conda-forge
scipy                     1.15.2          py311h8f841c2_0    conda-forge
seaborn                   0.13.2               hd8ed1ab_3    conda-forge
seaborn-base              0.13.2             pyhd8ed1ab_3    conda-forge
send2trash                1.8.3              pyh0d859eb_1    conda-forge
session-info2             0.1.2              pyhd8ed1ab_0    conda-forge
setuptools                80.9.0             pyhff2d567_0    conda-forge
six                       1.17.0             pyhe01879c_1    conda-forge
sniffio                   1.3.1              pyhd8ed1ab_1    conda-forge
soupsieve                 2.7                pyhd8ed1ab_0    conda-forge
stack_data                0.6.3              pyhd8ed1ab_1    conda-forge
statsmodels               0.14.5          py311hb0beb2c_0    conda-forge
tbb                       2022.2.0             hb60516a_0    conda-forge
terminado                 0.18.1             pyh0d859eb_0    conda-forge
texttable                 1.7.0              pyhd8ed1ab_1    conda-forge
threadpoolctl             3.6.0              pyhecae5ae_0    conda-forge
tinycss2                  1.4.0              pyhd8ed1ab_0    conda-forge
tk                        8.6.13          noxft_hd72426e_102    conda-forge
tomli                     2.2.1              pyhd8ed1ab_1    conda-forge
tornado                   6.5.1           py311h9ecbd09_0    conda-forge
tqdm                      4.67.1             pyhd8ed1ab_1    conda-forge
traitlets                 5.14.3             pyhd8ed1ab_1    conda-forge
types-python-dateutil     2.9.0.20250708     pyhd8ed1ab_0    conda-forge
typing-extensions         4.14.1               h4440ef1_0    conda-forge
typing_extensions         4.14.1             pyhe01879c_0    conda-forge
typing_utils              0.1.0              pyhd8ed1ab_1    conda-forge
tzdata                    2025b                h78e105d_0    conda-forge
umap-learn                0.5.9.post2     py311h38be061_0    conda-forge
unicodedata2              16.0.0          py311h9ecbd09_0    conda-forge
uri-template              1.3.0              pyhd8ed1ab_1    conda-forge
urllib3                   2.5.0              pyhd8ed1ab_0    conda-forge
wcwidth                   0.2.13             pyhd8ed1ab_1    conda-forge
webcolors                 24.11.1            pyhd8ed1ab_0    conda-forge
webencodings              0.5.1              pyhd8ed1ab_3    conda-forge
websocket-client          1.8.0              pyhd8ed1ab_1    conda-forge
wheel                     0.45.1             pyhd8ed1ab_1    conda-forge
widgetsnbextension        4.0.14             pyhd8ed1ab_0    conda-forge
wrapt                     1.17.2          py311h9ecbd09_0    conda-forge
xgboost                   3.0.2           cuda128_pyh68bd8d9_0    conda-forge
xorg-libxau               1.0.12               hb9d3cd8_0    conda-forge
xorg-libxdmcp             1.1.5                hb9d3cd8_0    conda-forge
yaml                      0.2.5                h7f98852_2    conda-forge
zarr                      3.1.0              pyhe01879c_0    conda-forge
zeromq                    4.3.5                h3b0a872_7    conda-forge
zipp                      3.23.0             pyhd8ed1ab_0    conda-forge
zstandard                 0.23.0          py311h9ecbd09_2    conda-forge
zstd                      1.5.7                hb8e6e7a_2    conda-forge

[amatoc]

Hi,
I got a similar error when trying to use the mouse version of hallmark genes (Friday, April 10, 2026)

HTTPError                                 Traceback (most recent call last)
Cell In[40], line 2
      1 #access the hallmark database for mouse
----> 2 hallmark = dc.op.hallmark(organism='mouse', license='academic')
      3 hallmark

File [~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/op/_hallmark.py:49](http://localhost:8888/lab/tree/Desktop/Fixed%20Seq/~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/op/_hallmark.py#line=48), in hallmark(organism, license, verbose)
     47 hm = _infer_dtypes(hm)
     48 if organism != "human":
---> 49     hm = translate(hm, columns=["genesymbol"], target_organism=organism, verbose=verbose)
     50 hm = hm.rename(columns={"geneset": "source", "genesymbol": "target"})
     51 hm = hm.drop_duplicates(["source", "target"]).reset_index(drop=True)

File [~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/op/_translate.py:185](http://localhost:8888/lab/tree/Desktop/Fixed%20Seq/~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/op/_translate.py#line=184), in translate(net, columns, target_organism, min_evidence, one_to_many, verbose)
    183 # Process orthologs
    184 url = f"[https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_{target_organism}_hcop_fifteen_column.txt.gz](https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_%7Btarget_organism%7D_hcop_fifteen_column.txt.gz)"
--> 185 map_df = _download(url, verbose=verbose)
    186 map_df = _bytes_to_pandas(map_df, low_memory=False, compression="gzip", sep="\t")
    187 map_df = pd.read_csv(url, sep="\t", low_memory=False)

File [~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/_download.py:23](http://localhost:8888/lab/tree/Desktop/Fixed%20Seq/~/anaconda3/envs/scanpy/lib/python3.13/site-packages/decoupler/_download.py#line=22), in _download(url, verbose)
     21 chunks = []
     22 with requests.get(url, stream=True) as r:
---> 23     r.raise_for_status()
     24     with tqdm(unit="B", unit_scale=True, desc="Progress", disable=not verbose) as pbar:
     25         for chunk in r.iter_content(chunk_size=8192):

File [~/anaconda3/envs/scanpy/lib/python3.13/site-packages/requests/models.py:1026](http://localhost:8888/lab/tree/Desktop/Fixed%20Seq/~/anaconda3/envs/scanpy/lib/python3.13/site-packages/requests/models.py#line=1025), in Response.raise_for_status(self)
   1021     http_error_msg = (
   1022         f"{self.status_code} Server Error: {reason} for url: {self.url}"
   1023     )
   1025 if http_error_msg:
-> 1026     raise HTTPError(http_error_msg, response=self)

HTTPError: 404 Client Error: Not Found for url: https://ftp.ebi.ac.uk/pub/databases/genenames/hcop/human_mouse_hcop_fifteen_column.txt.gz

using to retrieve the human (default) version worked fine, no error. I haven't tried any other species.

hm = dc.op.hallmark()
hm 

returned df 7318 rows x 2 columns (source and target)

versions
Python 3.13.5
decoupler 2.1.2

[easlinger]

I got similar errors today (April 10, 2026), so I tried looping through the list returned by dc.op.show_resources().name.tolist() for mouse, and none of them worked.

Python 3.13.5
anndata: 0.12.1
scanpy: 1.11.4
pandas: 2.2.3
numpy: 2.2.6
scipy: 1.15.3
decoupler: 2.1.5 (note I had the same problem with version 2.1.1)

for x in dc.op.show_resources().name.tolist():
    try:
        resource = dc.op.resource(x, organism="mouse")
        print(x + " worked!")
    except Exception as err:
        print(x + f" didn't work: {err}.")

[PauBadiaM]

Hi @stevenjbark , @amatoc and @easlinger , thanks for rising this issue! It seems that the table I was using for orthology conversion is no longer available through EBI's ftp site. @dbdimitrov I guess you are experiencing the same issue, any idea where they moved this now? 🤔 @deeenes maybe you know about it?

[PauBadiaM]

Never mind found the solution! I will make a release this weekend with the fix, in the meantime you can install the fixed version from github:

pip install git+https://github.com/scverse/decoupler.git@main

[stevenjbark]

So this has been corrected, but how can I download the new 2.1.6 bug fixed version? Do I need to wait for this to be submitted to PyPI and conda-forge?Sent from my iPhoneOn Apr 10, 2026, at 6:19 PM, Pau Badia i Mompel ***@***.***> wrote: Closed #303 as completed via #304. —Reply to this email directly, view it on GitHub, or unsubscribe.You are receiving this because you were mentioned.Message ID: ***@***.***>

[PauBadiaM]

@stevenjbark I will make a release this weekend, which will be available through PyPI and conda-forge, but in the meantime you can install directly from GitHub. Hope this is helpful!