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33scVelo - RNA velocity generalized through dynamical modeling
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10- **scVelo ** is a scalable toolkit for RNA velocity analysis in single cells.
11- The methods are based on our preprint
12- `Bergen et al. (2019) <https://doi.org/10.1101/820936 >`_.
10+ **scVelo ** is a scalable toolkit for RNA velocity analysis in single cells, based on
11+ `Bergen et al. (Nature Biotech, 2020) <https://doi.org/10.1038/s41587-020-0591-3 >`_.
1312
14- RNA velocity enables the recovery of directed dynamic information by leveraging splicing information.
15- scVelo generalizes the concept of RNA velocity (`La Manno et al., 2018 <https://doi.org/10.1038/s41586-018-0414-6 >`_)
13+ RNA velocity enables the recovery of directed dynamic information by leveraging splicing kinetics.
14+ scVelo generalizes the concept of RNA velocity
15+ (`La Manno et al., Nature, 2018 <https://doi.org/10.1038/s41586-018-0414-6 >`_)
1616by relaxing previously made assumptions with a stochastic and a dynamical model that solves the full
1717transcriptional dynamics. It thereby adapts RNA velocity to widely varying specifications such as non-stationary populations.
1818
1919scVelo is compatible with scanpy _ and hosts efficient implementations of all RNA velocity models.
2020
21- See `<https://scvelo.org >`_ for documentation and tutorials.
22-
2321scVelo's key applications
24- -------------------------
22+ ^^^^^^^^^^^^^^^^^^^^^^^^^
2523- estimate RNA velocity to study cellular dynamics.
2624- identify putative driver genes and regimes of regulatory changes.
2725- infer a latent time to reconstruct the temporal sequence of transcriptomic events.
2826- estimate reaction rates of transcription, splicing and degradation.
2927- use statistical tests, e.g., to detect different kinetics regimes.
3028
29+ scVelo has, for instance, recently been used to study immune response in COVID-19
30+ patients and dynamic processes in human lung regeneration. Find out more in this list of
31+ `application examples <https://scholar.google.com/scholar?cites=18195185735875895912 >`_.
32+
33+ Latest news
34+ ^^^^^^^^^^^
35+ - Feb/2021: scVelo goes multi-core
36+ - Dec/2020: Cover of `Nature Biotechnology <https://www.nature.com/nbt/volumes/38 >`_
37+ - Nov/2020: Talk at `Single Cell Biology <https://coursesandconferences.wellcomegenomecampus.org/our-events/single-cell-biology-2020/ >`_
38+ - Oct/2020: `Helmholtz Best Paper Award <https://twitter.com/ICBmunich/status/1318611467722199041 >`_
39+ - Oct/2020: Map cell fates with `CellRank <https://cellrank.org >`_
40+ - Sep/2020: Talk at `Single Cell Omics <https://twitter.com/fabian_theis/status/1305621028056465412 >`_
41+ - Aug/2020: `scVelo out in Nature Biotech <https://www.helmholtz-muenchen.de/en/aktuelles/latest-news/press-information-news/article/48658/index.html >`_
42+
3143Reference
32- ---------
33- Bergen et al. (2019), *Generalizing RNA velocity to transient cell states through dynamical modeling *,
34- `biorxiv <https://doi.org/10.1101/820936 >`_.
44+ ^^^^^^^^^
45+ Bergen *et al. * (2020), Generalizing RNA velocity to transient cell states through dynamical modeling,
46+ `Nature Biotech <https://doi.org/10.1038/s41587-020-0591-3 >`_.
47+ |dim |
3548
3649Support
37- -------
38- Feel free to submit an `issue <https://github.com/theislab/scvelo/issues/new/choose >`_
39- or send us an `email <mailto:mail@scvelo.org >`_.
50+ ^^^^^^^
51+ Found a bug or would like to see a feature implemented? Feel free to submit an
52+ `issue <https://github.com/theislab/scvelo/issues/new/choose >`_.
53+ Have a question or would like to start a new discussion? Head over to
54+ `GitHub discussions <https://github.com/theislab/scvelo/discussions >`_.
55+ In either case, you can also always send us an `email <mailto:mail@scvelo.org >`_.
4056Your help to improve scVelo is highly appreciated.
57+ For further information visit `scvelo.org <https://scvelo.org >`_.
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4360.. |PyPI | image :: https://img.shields.io/pypi/v/scvelo.svg
@@ -49,7 +66,16 @@ Your help to improve scVelo is highly appreciated.
4966.. |Docs | image :: https://readthedocs.org/projects/scvelo/badge/?version=latest
5067 :target: https://scvelo.readthedocs.io
5168
52- .. |travis | image :: https://travis-ci.org/theislab/scvelo.svg?branch=master
53- :target: https://travis-ci.org/theislab/scvelo
69+ .. |CI | image :: https://img.shields.io/github/workflow/status/theislab/scvelo/CI/master
70+ :target: https://github.com/theislab/scvelo/actions?query=workflow%3ACI
71+
72+ .. _scanpy : https://scanpy.readthedocs.io
73+
74+ .. |br | raw :: html
75+
76+ <br/>
77+
78+ .. |dim | raw :: html
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55- .. _scanpy : https://scanpy.readthedocs.io
80+ <span class="__dimensions_badge_embed__" data-id="pub.1129830274" data-style="small_rectangle"></span>
81+ <script async src="https://badge.dimensions.ai/badge.js" charset="utf-8"></script>
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