RAM requirements for gene-variant workup

[gdonahue]

Hi,

I am going through the workup on zenodo to generate gene-variant annotation using the provided data, but I find that R crashes at the aggregate step, specifically:

snpagg <- aggregate(snpcomb, list(snpcomb$ensg), unique)

Do you know how much RAM is required for this? If that is the issue I could run it on our cluster but I would like to have some idea first.

Additionally, I tried running it on Hi-C data of my own but hit the same wall.

Best, -G