diff --git a/packages/core/src/Select/Select.test.ts b/packages/core/src/Select/Select.test.ts
index 95eb4d8671..792b309aff 100644
--- a/packages/core/src/Select/Select.test.ts
+++ b/packages/core/src/Select/Select.test.ts
@@ -38,6 +38,69 @@ describe('given default Select', () => {
     expect(selectTrigger.attributes('data-placeholder')).toBe('')
   })
 
+  describe('trigger mouse interop', () => {
+    async function openSelectWithMouseClick() {
+      const button = wrapper.find('button')
+      // Open on pointerdown, then emit the compatibility mouse events that follow in browsers.
+      await button.trigger('pointerdown', { button: 0, ctrlKey: false })
+      fireEvent.mouseDown(button.element, { button: 0, ctrlKey: false })
+      fireEvent.mouseUp(button.element, { button: 0, ctrlKey: false })
+      fireEvent.click(button.element, { button: 0, ctrlKey: false })
+      await nextTick()
+      await nextTick()
+    }
+
+    it('should not suppress window mousedown listeners when opening (#1773)', async () => {
+      const button = wrapper.find('button').element
+      const onWindowMousedown = vi.fn()
+      window.addEventListener('mousedown', onWindowMousedown, true)
+
+      fireEvent.pointerDown(button, { button: 0, ctrlKey: false, pointerType: 'mouse' })
+      const mousedownEvent = new MouseEvent('mousedown', {
+        bubbles: true,
+        cancelable: true,
+        button: 0,
+        ctrlKey: false,
+      })
+      button.dispatchEvent(mousedownEvent)
+
+      expect(onWindowMousedown).toHaveBeenCalled()
+      expect(mousedownEvent.defaultPrevented).toBe(true)
+
+      window.removeEventListener('mousedown', onWindowMousedown, true)
+    })
+
+    it('should focus the trigger on click without a preceding pointerdown', async () => {
+      const trigger = wrapper.find('[role="combobox"]').element as HTMLElement
+      const focusSpy = vi.spyOn(trigger, 'focus')
+
+      fireEvent.click(trigger, { button: 0, ctrlKey: false })
+
+      expect(focusSpy).toHaveBeenCalled()
+      focusSpy.mockRestore()
+    })
+
+    it('should not re-focus the trigger on click after opening via pointerdown', async () => {
+      const trigger = wrapper.find('[role="combobox"]').element as HTMLElement
+      const focusSpy = vi.spyOn(trigger, 'focus')
+
+      await wrapper.find('button').trigger('pointerdown', { button: 0, ctrlKey: false })
+      fireEvent.click(trigger, { button: 0, ctrlKey: false })
+
+      expect(focusSpy).not.toHaveBeenCalled()
+      focusSpy.mockRestore()
+    })
+
+    it('should not leave focus on the trigger after opening via mouse click', async () => {
+      const trigger = wrapper.find('[role="combobox"]').element
+
+      await openSelectWithMouseClick()
+
+      expect(wrapper.html()).toContain('Apple')
+      expect(document.activeElement).not.toBe(trigger)
+    })
+  })
+
   describe('opening the modal', () => {
     beforeEach(async () => {
       await wrapper.find('button').trigger('pointerdown', {
diff --git a/packages/core/src/Select/SelectTrigger.vue b/packages/core/src/Select/SelectTrigger.vue
index c87a281a2e..7b5b243f25 100644
--- a/packages/core/src/Select/SelectTrigger.vue
+++ b/packages/core/src/Select/SelectTrigger.vue
@@ -47,6 +47,52 @@ function handlePointerOpen(event: PointerEvent) {
     y: Math.round(event.pageY),
   }
 }
+
+function isPlainLeftClick(event: MouseEvent) {
+  return event.button === 0 && event.ctrlKey === false
+}
+
+// Tracks direct mouse presses handled in `pointerdown` so the Safari label
+// `click` workaround below does not re-focus the trigger after opening.
+let openedFromPointerDown = false
+
+function onTriggerPointerDown(event: PointerEvent) {
+  // Prevent opening on touch down.
+  // https://github.com/unovue/reka-ui/issues/804
+  if (event.pointerType === 'touch')
+    return event.preventDefault()
+
+  // prevent implicit pointer capture
+  // https://www.w3.org/TR/pointerevents3/#implicit-pointer-capture
+  const target = event.target as HTMLElement
+  if (target.hasPointerCapture(event.pointerId))
+    target.releasePointerCapture(event.pointerId)
+
+  // only call handler if it's the left button (mousedown gets triggered by all mouse buttons)
+  // but not when the control key is pressed (avoiding MacOS right click)
+  if (isPlainLeftClick(event)) {
+    handlePointerOpen(event)
+    openedFromPointerDown = true
+  }
+}
+
+function onTriggerMouseDown(event: MouseEvent) {
+  // Prevent trigger from stealing focus from the active item after opening.
+  // We avoid calling `preventDefault` in `pointerdown` because that suppresses
+  // compatibility mouse events (`mousedown`, `mouseup`, `click`).
+  if (isPlainLeftClick(event))
+    event.preventDefault()
+}
+
+function onTriggerClick(event: MouseEvent) {
+  // Safari: label-associated clicks may not run `pointerdown` on the trigger.
+  // Direct mouse clicks open in `pointerdown` and must not re-focus the trigger
+  // here — `mousedown` `preventDefault` does not suppress `click`.
+  if (!openedFromPointerDown)
+    (event.currentTarget as HTMLElement)?.focus()
+
+  openedFromPointerDown = false
+}
 </script>
 
 <template>
@@ -69,39 +115,9 @@ function handlePointerOpen(event: PointerEvent) {
       :data-placeholder="shouldShowPlaceholder(rootContext.modelValue?.value) ? '' : undefined"
       :as-child="asChild"
       :as="as"
-      @click="
-        (event: MouseEvent) => {
-          // Whilst browsers generally have no issue focusing the trigger when clicking
-          // on a label, Safari seems to struggle with the fact that there's no `onClick`.
-          // We force `focus` in this case. Note: this doesn't create any other side-effect
-          // because we are preventing default in `onPointerDown` so effectively
-          // this only runs for a label 'click'
-          (event?.currentTarget as HTMLElement)?.focus();
-        }
-      "
-      @pointerdown="
-        (event: PointerEvent) => {
-          // Prevent opening on touch down.
-          // https://github.com/unovue/reka-ui/issues/804
-          if (event.pointerType === 'touch')
-            return event.preventDefault();
-
-          // prevent implicit pointer capture
-          // https://www.w3.org/TR/pointerevents3/#implicit-pointer-capture
-          const target = event.target as HTMLElement;
-          if (target.hasPointerCapture(event.pointerId)) {
-            target.releasePointerCapture(event.pointerId);
-          }
-
-          // only call handler if it's the left button (mousedown gets triggered by all mouse buttons)
-          // but not when the control key is pressed (avoiding MacOS right click)
-          if (event.button === 0 && event.ctrlKey === false) {
-            handlePointerOpen(event)
-            // prevent trigger from stealing focus from the active item after opening.
-            event.preventDefault();
-          }
-        }
-      "
+      @click="onTriggerClick"
+      @pointerdown="onTriggerPointerDown"
+      @mousedown="onTriggerMouseDown"
       @pointerup.prevent="
         (event: PointerEvent) => {
           // Only open on pointer up when using touch devices