| Prediction Target | Inclusion Criteria | Dataset Sizes | Performance |
|---|---|---|---|
| Alzheimer's Disease and Related Dementia and/or Prescriptions assiciated with ADRD in 1 year | Age: 50-100 years | National: Case: 53.9k, Control: 1.2M Chicago: Case: 3.4k, Control: 50.8k |
National: Males: AUC 85.4% (84.9%, 86.0%) Sensitivity 47.2% (46.1%, 48.2%) Positive LR: 9.26 (9.05, 9.47) Negative LR: 0.56 (0.57, 0.55) Females: AUC 86.8% (86.3%, 87.3%) Sensitivity 49.2% (48.3%, 50.1%) Positive LR: 9.65 (9.47, 9.83) Negative LR: 0.54 (0.54, 0.53) Chicago: Males: AUC 74.3% (72.4%, 76.3%) Sensitivity 32.4% (29.8%, 35.0%) Positive LR: 5.02 (4.62, 5.42) Negative LR: 0.72 (0.75, 0.69) Females: AUC 76.8% (75.4%, 78.3%) Sensitivity 33.0% (31.0%, 35.0%) Positive LR: 6.61 (6.21, 7.01) Negative LR: 0.71 (0.73, 0.68) |
| Alzheimer's Disease and Related Dementia and/or Prescriptions assiciated with ADRD and/or MCI in 1 year | Age: 50-100 years | National: Case: 60.3k, Control: 1.2M Chicago: Case: 4.1k, Control: 50.0k |
National: Males: AUC 84.1% (83.5%, 84.6%) Sensitivity 43.8% (42.8%, 44.8%) Positive LR: 8.60 (8.41, 8.80) Negative LR: 0.59 (0.60, 0.58) Females: AUC 86.0% (85.5%, 86.4%) Sensitivity 46.4% (45.5%, 47.2%) Positive LR: 9.28 (9.10, 9.45) Negative LR: 0.56 (0.57, 0.56) Chicago: Males: AUC 74.0% (72.2%, 75.8%) Sensitivity 31.6% (29.3%, 34.0%) Positive LR: 5.13 (4.75, 5.51) Negative LR: 0.73 (0.75, 0.70) Females: AUC 76.6% (75.3%, 77.9%) Sensitivity 28.2% (26.5%, 30.0%) Positive LR: 6.28 (5.89, 6.66) Negative LR: 0.75 (0.77, 0.73) |
| Idiopathic Pulmonary Fibrosis (J84.112) in 1 year | Age: 50-85 years | National: Case: 15.4k, Control: 2.8M Chicago: Case: 174, Control: 23.6k |
National: Males: AUC 87.3% (86.3%, 88.2%) Sensitivity 56.4% (54.6%, 58.3%) Positive LR: 9.41 (9.10, 9.72) Negative LR: 0.46 (0.48, 0.44) Females: AUC 89.3% (88.4%, 90.3%) Sensitivity 61.1% (59.1%, 63.1%) Positive LR: 11.98 (11.60, 12.37) Negative LR: 0.41 (0.43, 0.39) Chicago: Males: AUC 90.9% (86.8%, 95.0%) Sensitivity 72.6% (63.1%, 82.2%) Positive LR: 12.44 (10.81, 14.08) Negative LR: 0.29 (0.39, 0.19) Females: AUC 92.2% (88.6%, 95.8%) Sensitivity 71.1% (61.7%, 80.5%) Positive LR: 35.45 (30.78, 40.12) Negative LR: 0.29 (0.39, 0.20) |
| Interstitial Lung Diseases (J84.1,J84.89,J84.9) in 1 year | Age: 50-85 years | National: Case: 20.5k, Control: 851k |
National: Males: AUC 82.2% Sensitivity 38.8% Positive LR: 7.76 Negative LR: 0.64 Females: AUC 81.8% Sensitivity 37.6% Positive LR: 7.51 Negative LR: 0.66 |
| Chronic obstructive pulmonary disease (J44) in 1 year | Age: 50-85 years | National: Case: 207k, Control: 7.3M |
National: Males: AUC 81.0% Sensitivity 39.6% Positive LR: 7.91 Negative LR: 0.64 Females: AUC 82.2% Sensitivity 40.8% Positive LR: 8.16 Negative LR: 0.62 |
| ASD and related Pervasive Developmental Disorders (F84) by 4 years old | Age: Newborns, with records available for the first 2 years | National: Case: 18.9k, Control: 1.0M Chicago: Case: 48, Control: 632 |
National: Males: AUC 81.8% (80.9%, 82.6%) Sensitivity 46.7% (45.4%, 48.0%) Positive LR: 9.54 (9.28, 9.81) Negative LR: 0.56 (0.57, 0.55) Females: AUC 84.6% (83.2%, 86.0%) Sensitivity 56.2% (53.9%, 58.5%) Positive LR: 11.24 (10.78, 11.70) Negative LR: 0.46 (0.49, 0.44) Chicago: Males: AUC 77.0% (68.8%, 85.2%) Sensitivity 30.8% (16.3%, 45.3%) Positive LR: 5.99 (3.17, 8.81) Negative LR: 0.73 (0.88, 0.58) Females: AUC 88.7% (81.8%, 96.2%) Sensitivity 11.1% (0.0%, 31.6%) Positive LR: 33.44 (0.00, 95.25) Negative LR: 0.89 (1.10, 0.69) |
| Intensive Care Unit visit (G0390, G9657, 4168F, 99291) in 1 days to 2 weeks | Diagnosed with Acute Pancreatitis (K85) | National: Case: 12.6k, Control: 105k |
National: Males: AUC 92.3% Sensitivity 75.2% Positive LR: 15.05 Negative LR: 0.26 Females: AUC 92.5% Sensitivity 77.0% Positive LR: 15.40 Negative LR: 0.24 |
| Exocrine Pancreatic Insufficiency (K86.81) in 4 weeks to 2 years | Diagnosed with Acute Pancreatitis (K85) | National: Case: 1.2k, Control: 175k |
National: Males: AUC 92.1% Sensitivity 55.5% Positive LR: 11.09 Negative LR: 0.47 Females: AUC 92.5% Sensitivity 59.3% Positive LR: 11.87 Negative LR: 0.43 |
| Insulin Rx in 4 weeks to 1 years | Diagnosed with Acute Pancreatitis (K85) | National: Case: 5.8k, Control: 151k |
National: Males: AUC 87.2% Sensitivity 44.8% Positive LR: 8.95 Negative LR: 0.58 Females: AUC 88.9% Sensitivity 57.4% Positive LR: 11.49 Negative LR: 0.45 |
| Symptoms and signs specifically associated with systemic inflammation and infection (R65) in 1 year | Age: 50-85 years | National: Case: 21.9k, Control: 1.5M |
National: Males: AUC 85.9% Sensitivity 51.3% Positive LR: 10.26 Negative LR: 0.51 Females: AUC 86.0% Sensitivity 50.2% Positive LR: 10.04 Negative LR: 0.52 |
| Every Diagnosis associated with Chronic Kidney Disease (N18, I12, I13, D63.1, E08.22, E09.22, E10.22, E11.22, E13.22) and Hypertensive Chronic Kidney Disease (I12, I13) in 1 year | Age: 35-75 years; Excluded patients with pre-existing CKD complicating pregnancy (O10.2, O10.3) from Inference Window |
National: Case: 16.2k, Control: 581k Chicago: Case: 2.2k, Control: 31.6k |
National: Males: AUC 81.8% (80.7%, 82.8%) Sensitivity 38.2% (36.5%, 40.0%) Positive LR: 8.15 (7.78, 8.52) Negative LR: 0.65 (0.67, 0.63) Females: AUC 83.0% (81.8%, 84.1%) Sensitivity 41.1% (39.1%, 43.1%) Positive LR: 8.77 (8.35, 9.20) Negative LR: 0.62 (0.64, 0.60) Chicago: Males: AUC 77.6% (75.8%, 79.4%) Sensitivity 31.8% (29.1%, 34.4%) Positive LR: 5.60 (5.14, 6.07) Negative LR: 0.72 (0.75, 0.70) Females: AUC 81.7% (79.9%, 83.5%) Sensitivity 38.9% (35.9%, 41.9%) Positive LR: 7.36 (6.80, 7.93) Negative LR: 0.65 (0.68, 0.61) |
| Stage 4 and later of Chronic Kidney Disease (N18,), stage 5 or later of Hypertensive Chronic Kidney Disease (I12) and Hypertensive Heart and Chronic Kidney Disease without Heart Failure (I13) in 1 months to 2 years | Age: 35-75 years; Diagnosed with Stage 1-3 of Chronic Kidney Disease (N18) and Hypertensive Chronic Kidney Disease (I12) and Hypertensive Heart and Chronic Kidney Disease without Heart Failure (I13); Excluded patients with pre-existing CKD complicating pregnancy (O10.2, O10.3) from Inference Window |
National: Case: 18.3k, Control: 152k Chicago: Case: 244, Control: 979 |
National: Males: AUC 80.1% (79.1%, 81.1%) Sensitivity 33.3% (31.7%, 34.8%) Positive LR: 6.28 (5.98, 6.58) Negative LR: 0.70 (0.72, 0.69) Females: AUC 81.9% (80.7%, 83.0%) Sensitivity 38.2% (36.3%, 40.1%) Positive LR: 7.56 (7.18, 7.93) Negative LR: 0.65 (0.67, 0.63) Chicago: Males: AUC 79.4% (74.4%, 84.3%) Sensitivity 22.6% (15.0%, 30.3%) Positive LR: 10.42 (6.90, 13.94) Negative LR: 0.79 (0.87, 0.71) Females: AUC 74.5% (69.3%, 79.8%) Sensitivity 23.3% (16.0%, 30.5%) Positive LR: 5.49 (3.77, 7.21) Negative LR: 0.80 (0.88, 0.73) |
| Myalgic encephalomyelitis/chronic fatigue syndrome (G93.32) in 1 year | Age: 50-85 years | National: Case: 228, Control: 1.5M |
National: Males: AUC 93.2% Sensitivity 77.8% Positive LR: 15.56 Negative LR: 0.23 Females: AUC 96.0% Sensitivity 81.7% Positive LR: 16.33 Negative LR: 0.19 |
| Osteoporosis (M80-M81) in 1 year | Age: 50-85 years | National: Case: 113k, Control: 1.3M |
National: Males: AUC 79.5% Sensitivity 34.8% Positive LR: 6.96 Negative LR: 0.69 Females: AUC 74.4% Sensitivity 24.9% Positive LR: 4.98 Negative LR: 0.79 |
| Sarcopenia (M62.84) in 1 year | Age: 50-85 years | National: Case: 299, Control: 1.5M |
National: Males: AUC 91.0% Sensitivity 63.0% Positive LR: 12.61 Negative LR: 0.39 Females: AUC 91.9% Sensitivity 62.2% Positive LR: 12.44 Negative LR: 0.40 |
| Dementia (F00-F03, F05, F06.8) and degenerative diseases of the nervous system (G30-G32) in 1 year | Age: 50-85 years | National: Case: 78.1k, Control: 1.4M |
National: Males: AUC 87.8% Sensitivity 52.7% Positive LR: 10.53 Negative LR: 0.50 Females: AUC 88.5% Sensitivity 54.5% Positive LR: 10.90 Negative LR: 0.48 |
| Degeneration of macula and posterior pole (H35) in 1 year | Age: 50-85 years | National: Case: 114k, Control: 1.3M |
National: Males: AUC 82.1% Sensitivity 35.0% Positive LR: 7.00 Negative LR: 0.68 Females: AUC 80.7% Sensitivity 31.9% Positive LR: 6.38 Negative LR: 0.72 |
| Major depressive disorder, single (F32) and recurrent (F33) episode in 1 year | Age: 50-85 years | National: Case: 164k, Control: 1.2M |
National: Males: AUC 80.5% Sensitivity 38.6% Positive LR: 7.73 Negative LR: 0.65 Females: AUC 79.7% Sensitivity 32.4% Positive LR: 6.47 Negative LR: 0.71 |
| Osteoarthritis (M15-M19) in 1 year | Age: 50-85 years | National: Case: 359k, Control: 871k |
National: Males: AUC 72.5% Sensitivity 22.5% Positive LR: 4.50 Negative LR: 0.82 Females: AUC 73.5% Sensitivity 23.2% Positive LR: 4.64 Negative LR: 0.81 |
| Systemic connective tissue disorders (M30-M36) in 6 months to 1 years | Age: 50-85 years | National: Case: 24.8k, Control: 1.0M |
National: Males: AUC 72.0% Sensitivity 22.9% Positive LR: 4.58 Negative LR: 0.81 Females: AUC 73.2% Sensitivity 26.5% Positive LR: 5.31 Negative LR: 0.77 |
| Cerebral infarction (I63) in 1 year | Age: 50-85 years | National: Case: 57.9k, Control: 1.4M |
National: Males: AUC 81.1% Sensitivity 36.8% Positive LR: 7.37 Negative LR: 0.66 Females: AUC 82.9% Sensitivity 39.5% Positive LR: 7.90 Negative LR: 0.64 |
| Age-related physical debility (R54) in 1 year | Age: 50-85 years | National: Case: 4.7k, Control: 1.5M |
National: Males: AUC 96.2% Sensitivity 84.9% Positive LR: 16.98 Negative LR: 0.16 Females: AUC 95.6% Sensitivity 82.4% Positive LR: 16.47 Negative LR: 0.19 |
| Hearing Loss (H90-H95) in 1 year | Age: 50-85 years | National: Case: 221k, Control: 1.2M |
National: Males: AUC 72.7% Sensitivity 22.5% Positive LR: 4.49 Negative LR: 0.82 Females: AUC 72.4% Sensitivity 22.2% Positive LR: 4.44 Negative LR: 0.82 |
| Parkinson's Disease (G20) in 1 year | Age: 50-85 years | National: Case: 10.4k, Control: 1.5M |
National: Males: AUC 87.9% Sensitivity 54.6% Positive LR: 10.93 Negative LR: 0.48 Females: AUC 87.7% Sensitivity 52.0% Positive LR: 10.40 Negative LR: 0.51 |
| Mild Cognitive Impairment (F01-F03, G31) in 1 year | Age: 50-85 years | National: Case: 37.6k, Control: 1.5M |
National: Males: AUC 91.6% Sensitivity 65.3% Positive LR: 13.06 Negative LR: 0.37 Females: AUC 92.0% Sensitivity 66.5% Positive LR: 13.31 Negative LR: 0.35 |
| Intentional Self Harm (X71-X83), Suicidal Ideations (R45.851), Suicide Attempts (T14.91) in 1 year | Age: 50-85 years | National: Case: 5.2k, Control: 1.5M |
National: Males: AUC 83.9% Sensitivity 49.5% Positive LR: 9.90 Negative LR: 0.53 Females: AUC 86.2% Sensitivity 51.4% Positive LR: 10.29 Negative LR: 0.51 |
| Myocardial Infarction or Cardiac Arrest within 4 weeks following Total Hip/Knee Arthroplasty surgery | 45+ years old patients undergoing Total Hip/Knee Arthroplasty | National: Case: 882, Control: 444k |
National: Males: AUC 80.1% Sensitivity 35.1% Females: AUC 80.0% Sensitivity 36.4% |