Map Survey Instruments to Standard Terminology

Each survey question was reviewed and mapped to standard terminology concepts (e.g., NIH CDEs, SNOMED CT, LOINC or OMOP standards) to ensure interoperability and alignment with AI-READI's data harmonization goals.

• Map data elements to standard concepts using the OMOP CDM vocabulary and established concept relationships.
• Apply FAIR principles (Findable, Accessible, Interoperable, Reusable) through tools such as FAIRshare.
• Manage variable extensions and create custom concepts to address terminology gaps.

Mapping Overview

Standard Terminology Mappings Explained

The following table illustrates how specific variables from the AI-READI REDCap survey instruments are mapped to standard terminology concepts (e.g., SNOMED CT, LOINC) using OHDSI's Athena vocabulary for interoperability. These mappings ensure alignment with AI-READI's data harmonization goals.

1. Simple Mapping Case

Variable	Domain_id	Concept Code	Maps to Concept_id	URL	Additional Details
Marital Status	Observation	SNOMED 125680007	4053609	Value_as_concept_id: “Married” concept_id: 4338692
Troponin-T	Measurement	LOINC 67151-1	40769783	Code Description: Troponin T.cardiac [Mass/volume] in Serum or Plasma by High sensitivity method

2. Gaps – Survey questions that cannot be mapped when no standard terminology exists

Survey Question	Domain_id	Concept Code	Maps to Concept_id	URL	Additional Details
Worrying about the future and the possibility of serious complications	Observation	[TBD]	2005200046	Likely from PAID-5 survey; Maps to diabetes distress concept
How often have you been treated unfairly by teachers and professors because of your race/ethnic group?	Observation	[TBD]	2005200126	Likely from Social Determinants of Health survey; Maps to racial/ethnic discrimination concept

3. Complex - Both the survey question and its corresponding response must be combined to map the data accurately. A dual mapping approach was applied to capture both the answer response and the self-reported condition in the Condition domain.

#	Survey Question	Response Options
First part of the question	Has a doctor or other healthcare professional ever told you that you have/had a heart attack?	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 1	Other heart issues (e.g., pacemaker, heart valve disease, open heart surgery)	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 2	Stroke	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 3	Circulation problems (e.g., arteriosclerosis, atherosclerosis, blood clots in lungs or leg veins)	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 4	High blood cholesterol	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 5	High blood pressure	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 6	Low blood pressure	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 7	Parkinson’s disease	☐ Yes ☐ No ☐ Prefer not to say
Second part of the question - option 8	Dementia (e.g., Alzheimer’s disease, vascular dementia, etc.)	☐ Yes ☐ No ☐ Prefer not to say

Dual Map Explained

3a. Map to Observation Domain

Survey Question	Answer	Mapping Details
Has a doctor or other healthcare professional ever told you that you have/had any of the following conditions	Myocardial infarction	observation_concept_id: 2005200014 qualifier_concept_id: 4329847 qualifier_source_value: Myocardial infarction observation_type_concept_id: 32862 (survey type concept) value_as_concept_id: 4188539 (yes), 4188540 (no), 36311156 (prefer not to say)
Has a doctor or other healthcare professional ever told you that you have/had any of the following conditions	Type 2 diabetes mellitus	observation_concept_id: 2005200014 qualifier_concept_id: 201826 qualifier_source_value: Type 2 diabetes mellitus observation_type_concept_id: 32862 (survey type concept) value_as_concept_id: 4188539 (yes), 4188540 (no), 36311156 (prefer not to say)

3b. Map to Condition Domain

Survey Question	Response	Condition Concept Mapping
Has a doctor or other healthcare professional ever told you that you have/had any of the following conditions	Yes – Type 2 diabetes mellitus	condition_concept_id: 201820 qualifier_concept_id: 201826 qualifier_source_value: Type 2 diabetes mellitus condition_type_concept_id: 45905770 (patient reported)