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"title": "PyPeakRanker: Reproducible Peak-Level Feature Extraction for Regulatory Element Ranking",
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"title": "PyPeakRankR: Reproducible Peak-Level Feature Extraction for Regulatory Element Ranking",
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"description": "A Python package for extracting quantitative features from genomic peaks and assembling them into a reproducible, analysis-ready feature table.",
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"upload_type": "software",
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"license": "MIT",
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"doi": "10.5281/zenodo.15238527",
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"creators": [
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{
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"name": "Somasundaram, Saroja",
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"affiliation": "Allen Institute for Brain Science",
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"orcid": "0000-0002-3729-9849"
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},
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{
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"name": "Johansen, Nelson J.",
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"affiliation": "Allen Institute for Brain Science",
from **peak ranking** (user-defined, flexible). This ensures ranking logic
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remains transparent and adaptable to specific biological questions.
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@@ -162,31 +162,33 @@ remains transparent and adaptable to specific biological questions.
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## Used in
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PyPeakRanker was used in the following published studies:
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PyPeakRankR was used in the following published studies:
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-**Johansen et al. (2025)** — [Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex](https://doi.org/10.1016/j.xgen.2025.100879). *Cell Genomics.*
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PeakRankR ranked among the top 3 methods in the BICCN community challenge across 16 competing methods.
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-**Wirthlin et al. (2026)** — [A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia](https://doi.org/10.64898/2026.02.23.706695). *bioRxiv.*
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PyPeakRanker was used in the Cross-species Enhancer Ranking Pipeline (CERP) to compute ATAC specificity, PhyloP conservation, GC content, signal moments, and composite rankings for 514 candidate enhancers across basal ganglia cell types in mouse and macaque.
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PyPeakRankR was used in the Cross-species Enhancer Ranking Pipeline (CERP) to compute ATAC specificity, PhyloP conservation, GC content, signal moments, and composite rankings for 514 candidate enhancers across basal ganglia cell types in mouse and macaque.
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---
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## Citation
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If you use PyPeakRanker in your research, please cite:
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If you use PyPeakRankR in your research, please cite:
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> Somasundaram, S. (2026). PyPeakRanker: Reproducible Peak-Level Feature
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> Extraction for Regulatory Element Ranking.
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> Somasundaram, S. and Johansen, N.J. (2026). PyPeakRankR: Reproducible Peak-Level
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> Feature Extraction for Regulatory Element Ranking.
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