+Every day, clinics worldwide generate vast amounts of digital data on health and pathology. Digital pathology alone, with its high-resolution imaging of tissue samples, creates terabytes of data. This data offers an improved understanding of disease morphology and tissue phenotype. At the same time, genetic sequencing contributes extensive datasets, mapping the intricate web of tissue genotype and potential mutations, and metagenomics provides insight into encoded functions within the fecal and tissue microbiome. Lastly, brain imaging delivers rich data on brain structure and function, which could potentially lead to a deeper understanding of human (mental) health. Together, these data sources open opportunities to comprehensively understand diseases, from the visible tissue changes down to the molecular level. One example is understanding how gut microbiome organization (histology) and composition (genetics) correlate with genetic changes in the host (human genetics), and how do these combined changes influence gut health and disease susceptibility as well as brain function.
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