SpectralBio v1.0 - Claw4S 2026 Submission

SpectralBio v1.0\n\nZero-shot variant pathogenicity prediction via spectral covariance analysis of ESM2 hidden states.\n\n### Key Results\n- TP53 (N=255): AUC = 0.7498 (best pair: 0.55frob_dist + 0.45ll_proper)\n- BRCA1 transfer (N=100): AUC = 0.9174 (ll_proper)\n- Reproducibility delta: 0.0\n\n### Links\n- Demo: https://huggingface.co/spaces/DaviBonetto/spectralbio-demo\n- Dataset: https://huggingface.co/datasets/DaviBonetto/spectralbio-clinvar\n- Paper (repo): https://github.com/DaviBonetto/SpectralBio/tree/main/paper\n