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cdiff_invasion

This repository contains code and data to reproduce analyses for the manuscript Metabolic modeling enables personalized Clostridioides difficile engraftment predictions in the human gut.

  • Data tables containing processed genus level composition predicted growth rates and fluxes can be found the data folder, tables exceeding 25 MB can be founder here: 10.5281/zenodo.13315667.
  • Scripts used to process raw sequencing data with QIIME2 can be found in the scripts/QIIME2 folder
  • Scripts used to generate predicted growth rates and fluxes can be found in the scripts/Micom folder
  • Jupyter notebooks used for data analysis and the production of figures in the manuscript can be found in the notebooks folder
  • The conda environemnt used in the metabolic modeling analyses can be reproduced using the micom.yaml file and the command conda env create -f micom.yaml

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