Update CAM-KP (Causal Activity Models Knowledge Provider) resource entry

[caufieldjh]

Significantly expand the cam-kp resource page from a minimal stub to a comprehensive entry with detailed documentation.

CAM-KP Overview:

• Web service knowledge graph integrating causal biological and chemical models
• Part of NCATS Biomedical Data Translator initiative
• Combines Gene Ontology CAMs, Reactome pathways, and CTD chemical-gene interactions

Data Content:

• 750,000+ Gene Ontology annotations from 150,000+ publications
• Complete Reactome pathway models converted to causal representations
• 3.8 million chemical-gene interactions from CTD (17,700+ chemicals, 55,400 genes)
• RDF triplestore with OWL 2 reasoning over 39+ integrated ontologies

Access Methods:

• SPARQL endpoint (stars-app.renci.org/cam/sparql)
• TRAPI-compliant REST API (cam-kp-api-dev.renci.org/1.2.0/query)
• Automat platform integration (automat.renci.org/#/cam-kp)

Products:

• SPARQL endpoint for semantic queries
• TRAPI REST API for programmatic access
• Automat interface for knowledge discovery
• GO-CAM, Reactome, and CTD model representations
• Comprehensive API documentation

Key Features:

• Semantic web standards (RDF, OWL, SPARQL)
• Biolink Model compliance for universal schema
• Integration with Translator ecosystem
• Support for mechanistic hypothesis generation
• Applications: drug discovery, toxicology, environmental health

Organization:

• Led by Jim Balhoff (RENCI)
• Hosted at RENCI, UNC Chapel Hill
• Funded by NCATS/NIH
• Archived May 23, 2024; service remains operational

Standards & Interoperability:

• Biolink Model standardization
• TRAPI compliance for federated querying
• OBO Foundry ontologies (39+ integrated)
• JSON-LD for semantic context