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Mmaycon/README.md

Maycon Marção

🧬 Translational Bioinformatics Analyst
🏥 Center of Spatial OMICs -- St. Jude Children's Research Hospital
🧪 Pharmaceutical Sciences degree


About Me

I work at the intersection of spatial omics, cancer biology, and translational reasoning.

My focus is not just statistical discovery, but mechanistic interpretation. I design reproducible computational workflows that integrate single-cell and spatial transcriptomics with therapeutic logic, clinical covariates, and biological coherence.

With training in Pharmaceutical Sciences and Biotechnology, I bring pathophysiology awareness and treatment-effect intuition into computational oncology research.

From study design to publication-ready figures, I’m your guy.


Research Focus

  • Spatial transcriptomics (Visium, Xenium, CosMx, GeoMx, Phenocycler)
  • Single-cell RNA-seq analysis
  • Bulk RNA-seq analysis
  • DNA methylation modeling (450k and EPIC Illumina array)
  • Machine learning for biological phenotyping
  • Treatment-response and stemness modeling
  • Translational hypothesis generation

Selected Contributions

  • Co-author -- Nature Biotechnology (Spatial transcriptomics reproducibility standards)
  • Co-author -- Cell (STAMP multimodal spatial analysis framework)
  • Multiple publications on machine learning--based stemness modeling in cancer

Technical Stack

Languages and Frameworks: R, Python, Shell, Streamlit

Bioinformatics Packages & Toolkits:
Seurat, Scanpy, spacec, rapids-singlecell, scverse, SOPA, DESeq2, WGCNA, clusterProfiler, GSEA, minfi, caret, randomForest, scikit-learn, STAR, CellRanger, SpaceRanger, FeatureCounts

Spatial Omics Platforms:
Visium, Xenium, CosMx, GeoMx, Phenocycler

Reproducibility & Workflow:
Git, GitHub, Conda, NextFlow, structured project architecture

Data Submission & Compliance:
GEO-compliant multi-omics dataset preparation and metadata standardization

Management tools:
Notion, Clockify, Office tools, BioRender & Inkscape (Paper Figure Editing), BOX (data sharing), ChatGPT, Claude AI


Leadership & Engagement

  • Team Lead -- St. Jude BioHackathon 2025\
  • Intern Mentor -- Center of Spatial Omics\
  • Poster Presenter -- Society for Neuro-Oncology\
  • Contributor -- Space Hack 3.0

Professional Direction

Developing toward a hybrid role combining:

  • Lead bioinformatics infrastructure\
  • Translational oncology strategy\

🔗 GitHub: https://github.com/Mmaycon
🔗 LinkedIn: https://github.com/Mmaycon
🔗 Publications: https://scholar.google.com/citations?user=ACk8bV4AAAAJ&hl=en
🔗 St. Jude, Dr. Plummer Team: https://www.stjude.org/research/labs/plummer-lab/plummer-lab-team.html

Pinned Loading

  1. GEOScouter GEOScouter Public

    GEOScouter – a tool to save you time when profiling public datasets on the Gene Expression Omnibus (GEO).

    Python

  2. saha-project/SAHA saha-project/SAHA Public

    Reproducible figure generation, data, and methods for the Spatial Atlas of Human Anatomy (SAHA) project.

    Jupyter Notebook 5

  3. CSO_SpatialVis CSO_SpatialVis Public

    Python