Octopus Neuron Simulation

Instructions to Run

1. Install NEURON 8.2 Simulation Environment.

2. Compile Mod Files:

   • Compile the mod files in the folder into a new special.
   • Alternatively, drag and drop the folder of interest into the mknrndll application icon in NEURON.

3. Run the Simulation:

   • Open Terminal and navigate to the directory containing this file.
   • Execute one of the following commands:
     • For a full morphologically realistic simulation:

       mod/x86_64/special init-octopus-simulation.hoc

     • For a reduced compartment simulation:

       mod/x86_64/special Original_test_octopus_spencer_stick.hoc

4. Mimic Kv and HCN Block or Control Conditions:

   • To mimic Kv and HCN block, set scl and ghf to 0.
   • To mimic control conditions, set scl to 1e-1 and ghf to 1.

5. Tune Conductance:

   • Excitatory and inhibitory conductance can be adjusted from the GUI.