Quinidine-Model

Whole-body parent-metabolite PBPK model of quinidine as CYP2D6 perpetrator and CYP3A4 and P-gp victim drug

Repository files

A whole-body PBPK model of quinidine, evaluated within a comprehensive CYP2D6-CYP3A4-P-gp DD(G)I modeling network is provided. The model snapshot contains simulations of the clinical studies used during model development, including the respective observed data digitized from literature reports. For further details, please refer to [1].

Version information

OSP Version 11.0

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Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Feick D, Rüdesheim S, Marok FZ, Selzer D, Loer HLH, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug–drug–gene interaction network. CPT Pharmacometrics Syst Pharmacol 2023. DOI: 10.1002/psp4.12981.