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<!DOCTYPE html>
<html lang="zh-CN">
<head>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>抗体从头生成工具 - BioGen AI</title>
<script src="https://cdn.tailwindcss.com"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/animejs/3.2.1/anime.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/matter-js/0.19.0/matter.min.js"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/p5.js/1.7.0/p5.min.js"></script>
<script src="https://cdn.jsdelivr.net/npm/echarts@5.4.3/dist/echarts.min.js"></script>
<link href="https://fonts.googleapis.com/css2?family=Inter:wght@300;400;500;600;700;800&display=swap" rel="stylesheet">
<style>
* {
font-family: 'Inter', sans-serif;
}
body {
background: linear-gradient(135deg, #1a365d 0%, #2d3748 50%, #1a202c 100%);
min-height: 100vh;
}
.glass-card {
background: rgba(255, 255, 255, 0.1);
backdrop-filter: blur(10px);
border: 1px solid rgba(255, 255, 255, 0.2);
}
.nav-blur {
backdrop-filter: blur(20px);
background: rgba(26, 54, 93, 0.9);
}
.sequence-input {
font-family: 'JetBrains Mono', monospace;
background: rgba(0, 0, 0, 0.3);
border: 1px solid rgba(56, 178, 172, 0.3);
color: white;
}
.sequence-input:focus {
border-color: #38b2ac;
box-shadow: 0 0 0 3px rgba(56, 178, 172, 0.1);
}
.progress-bar {
background: linear-gradient(90deg, #38b2ac, #ed8936);
height: 8px;
border-radius: 4px;
width: 0%;
transition: width 0.3s ease;
}
.parameter-slider {
-webkit-appearance: none;
appearance: none;
height: 6px;
border-radius: 3px;
background: rgba(255, 255, 255, 0.2);
outline: none;
}
.parameter-slider::-webkit-slider-thumb {
-webkit-appearance: none;
appearance: none;
width: 20px;
height: 20px;
border-radius: 50%;
background: #38b2ac;
cursor: pointer;
}
.parameter-slider::-moz-range-thumb {
width: 20px;
height: 20px;
border-radius: 50%;
background: #38b2ac;
cursor: pointer;
border: none;
}
.result-card {
background: rgba(255, 255, 255, 0.05);
border: 1px solid rgba(255, 255, 255, 0.1);
border-radius: 12px;
padding: 1.5rem;
margin-bottom: 1rem;
transition: all 0.3s ease;
}
.result-card:hover {
background: rgba(255, 255, 255, 0.08);
transform: translateY(-2px);
}
.affinity-badge {
background: linear-gradient(135deg, #38b2ac, #319795);
color: white;
padding: 0.25rem 0.75rem;
border-radius: 9999px;
font-size: 0.75rem;
font-weight: 600;
}
.stability-badge {
background: linear-gradient(135deg, #ed8936, #dd6b20);
color: white;
padding: 0.25rem 0.75rem;
border-radius: 9999px;
font-size: 0.75rem;
font-weight: 600;
}
.visualization-3d {
background: radial-gradient(circle at center, rgba(56, 178, 172, 0.1), transparent);
border-radius: 12px;
min-height: 400px;
display: flex;
align-items: center;
justify-content: center;
position: relative;
overflow: hidden;
}
.molecule-rotation {
animation: rotate 20s linear infinite;
}
@keyframes rotate {
from { transform: rotateY(0deg); }
to { transform: rotateY(360deg); }
}
.loading-spinner {
width: 40px;
height: 40px;
border: 4px solid rgba(56, 178, 172, 0.3);
border-top: 4px solid #38b2ac;
border-radius: 50%;
animation: spin 1s linear infinite;
}
@keyframes spin {
0% { transform: rotate(0deg); }
100% { transform: rotate(360deg); }
}
</style>
</head>
<body>
<!-- Navigation -->
<nav class="fixed top-0 left-0 right-0 z-50 nav-blur border-b border-white/10">
<div class="max-w-7xl mx-auto px-6 py-4">
<div class="flex items-center justify-between">
<div class="flex items-center space-x-3">
<div class="w-10 h-10 bg-gradient-to-br from-teal-400 to-orange-500 rounded-lg flex items-center justify-center">
<span class="text-white font-bold text-lg">B</span>
</div>
<span class="text-white text-xl font-bold">BioGen AI</span>
</div>
<div class="hidden md:flex items-center space-x-8">
<a href="index.html" class="text-white hover:text-teal-400 transition-colors">首页</a>
<a href="antibody.html" class="text-teal-400 font-medium">抗体生成</a>
<a href="binder.html" class="text-white hover:text-teal-400 transition-colors">Binder设计</a>
<a href="biomni.html" class="text-white hover:text-teal-400 transition-colors">AI问答</a>
</div>
<button class="bg-gradient-to-r from-teal-500 to-orange-500 text-white px-6 py-2 rounded-lg font-medium hover:shadow-lg transition-all">
保存项目
</button>
</div>
</div>
</nav>
<!-- Main Content -->
<div class="pt-24 pb-12">
<div class="max-w-7xl mx-auto px-6">
<!-- Header -->
<div class="text-center mb-12">
<h1 class="text-4xl md:text-5xl font-bold text-white mb-4">
抗体从头生成工具
</h1>
<p class="text-xl text-gray-400 max-w-3xl mx-auto">
基于深度学习的抗体序列设计平台，支持高亲和力抗体的从头生成和优化
</p>
</div>
<!-- Tool Interface -->
<div class="grid lg:grid-cols-3 gap-8">
<!-- Left Panel - Input & Parameters -->
<div class="lg:col-span-1 space-y-6">
<!-- Antigen Input -->
<div class="glass-card rounded-2xl p-6">
<h3 class="text-xl font-bold text-white mb-4">目标抗原序列</h3>
<div class="space-y-4">
<div>
<label class="block text-sm font-medium text-gray-300 mb-2">
抗原序列 (FASTA格式)
</label>
<textarea
id="antigen-sequence"
class="sequence-input w-full h-32 p-3 rounded-lg resize-none focus:outline-none"
placeholder="请输入抗原氨基酸序列，例如：\nMKTLL..."
></textarea>
</div>
<div>
<label class="block text-sm font-medium text-gray-300 mb-2">
抗体类型
</label>
<select class="w-full p-3 bg-black/30 border border-white/20 rounded-lg text-white focus:outline-none focus:border-teal-400">
<option value="igg">IgG</option>
<option value="igm">IgM</option>
<option value="iga">IgA</option>
<option value="igd">IgD</option>
<option value="ige">IgE</option>
</select>
</div>
</div>
</div>
<!-- Parameters -->
<div class="glass-card rounded-2xl p-6">
<h3 class="text-xl font-bold text-white mb-4">设计参数</h3>
<div class="space-y-6">
<div>
<label class="block text-sm font-medium text-gray-300 mb-2">
亲和力要求 (KD)
</label>
<input type="range" class="parameter-slider w-full" min="0.1" max="10" value="1" step="0.1">
<div class="flex justify-between text-xs text-gray-400 mt-1">
<span>0.1 nM</span>
<span id="affinity-value">1.0 nM</span>
<span>10 nM</span>
</div>
</div>
<div>
<label class="block text-sm font-medium text-gray-300 mb-2">
稳定性权重
</label>
<input type="range" class="parameter-slider w-full" min="0.1" max="1" value="0.7" step="0.1">
<div class="flex justify-between text-xs text-gray-400 mt-1">
<span>低</span>
<span id="stability-value">中等</span>
<span>高</span>
</div>
</div>
<div>
<label class="block text-sm font-medium text-gray-300 mb-2">
生成数量
</label>
<input type="range" class="parameter-slider w-full" min="3" max="20" value="5" step="1">
<div class="flex justify-between text-xs text-gray-400 mt-1">
<span>3</span>
<span id="quantity-value">5</span>
<span>20</span>
</div>
</div>
</div>
<button
id="generate-antibody"
class="w-full mt-6 bg-gradient-to-r from-teal-500 to-teal-600 text-white py-3 rounded-lg font-semibold text-lg hover:shadow-lg transition-all"
>
开始生成抗体
</button>
</div>
<!-- Progress -->
<div class="glass-card rounded-2xl p-6" id="generation-progress" style="display: none;">
<h3 class="text-lg font-bold text-white mb-4">生成进度</h3>
<div class="bg-gray-700 rounded-full h-2 mb-2">
<div id="progress-bar" class="progress-bar"></div>
</div>
<div class="flex justify-between text-sm text-gray-400">
<span>正在优化CDR区域...</span>
<span id="progress-text">0%</span>
</div>
</div>
</div>
<!-- Center Panel - 3D Visualization -->
<div class="lg:col-span-1">
<div class="glass-card rounded-2xl p-6 h-full">
<h3 class="text-xl font-bold text-white mb-4">3D结构预览</h3>
<div class="visualization-3d">
<div class="text-center">
<div class="w-32 h-32 mx-auto mb-4 relative">
<!-- Antibody structure representation -->
<div class="molecule-rotation">
<svg viewBox="0 0 200 200" class="w-full h-full">
<!-- Antibody Y shape -->
<path d="M100 50 L80 80 L100 70 L120 80 Z" fill="#38b2ac" opacity="0.8"/>
<path d="M70 90 L50 130 L70 110 L90 130" fill="#ed8936" opacity="0.8"/>
<path d="M130 90 L150 130 L130 110 L110 130" fill="#ed8936" opacity="0.8"/>
<circle cx="100" cy="60" r="8" fill="#4299e1" opacity="0.9"/>
<circle cx="60" cy="120" r="6" fill="#4299e1" opacity="0.9"/>
<circle cx="140" cy="120" r="6" fill="#4299e1" opacity="0.9"/>
</svg>
</div>
</div>
<p class="text-gray-400 text-sm">抗体结构示意图</p>
<p class="text-gray-500 text-xs mt-2">生成后将显示详细的3D分子结构</p>
</div>
</div>
<!-- Statistics -->
<div class="mt-6 grid grid-cols-2 gap-4">
<div class="text-center p-4 bg-white/5 rounded-lg">
<div class="text-2xl font-bold text-teal-400" id="success-rate">95%</div>
<div class="text-sm text-gray-400">成功率</div>
</div>
<div class="text-center p-4 bg-white/5 rounded-lg">
<div class="text-2xl font-bold text-orange-400" id="avg-affinity">0.5nM</div>
<div class="text-sm text-gray-400">平均亲和力</div>
</div>
</div>
</div>
</div>
<!-- Right Panel - Results -->
<div class="lg:col-span-1">
<div class="glass-card rounded-2xl p-6 h-full">
<h3 class="text-xl font-bold text-white mb-4">生成结果</h3>
<div id="antibody-results" style="display: none;">
<!-- Results will be populated by JavaScript -->
</div>
<div id="no-results" class="text-center py-12">
<div class="w-16 h-16 bg-white/10 rounded-full flex items-center justify-center mx-auto mb-4">
<svg class="w-8 h-8 text-gray-400" fill="none" stroke="currentColor" viewBox="0 0 24 24">
<path stroke-linecap="round" stroke-linejoin="round" stroke-width="2" d="M9 12h6m-6 4h6m2 5H7a2 2 0 01-2-2V5a2 2 0 012-2h5.586a1 1 0 01.707.293l5.414 5.414a1 1 0 01.293.707V19a2 2 0 01-2 2z"></path>
</svg>
</div>
<p class="text-gray-400">点击"开始生成抗体"查看结果</p>
</div>
</div>
</div>
</div>
</div>
</div>
<!-- Technical Details -->
<section class="py-16 bg-black/20">
<div class="max-w-7xl mx-auto px-6">
<div class="text-center mb-12">
<h2 class="text-3xl font-bold text-white mb-4">技术原理</h2>
<p class="text-gray-400 max-w-3xl mx-auto">
基于深度学习的抗体重头生成算法，结合物理约束和进化信息
</p>
</div>
<div class="grid md:grid-cols-3 gap-8">
<div class="text-center">
<div class="w-16 h-16 bg-gradient-to-br from-teal-500 to-teal-600 rounded-2xl flex items-center justify-center mx-auto mb-4">
<span class="text-white text-2xl">🧠</span>
</div>
<h3 class="text-xl font-bold text-white mb-2">深度学习模型</h3>
<p class="text-gray-400 text-sm">
使用Transformer架构和扩散模型，学习抗体序列的深层特征和结构约束
</p>
</div>
<div class="text-center">
<div class="w-16 h-16 bg-gradient-to-br from-orange-500 to-orange-600 rounded-2xl flex items-center justify-center mx-auto mb-4">
<span class="text-white text-2xl">⚡</span>
</div>
<h3 class="text-xl font-bold text-white mb-2">物理约束优化</h3>
<p class="text-gray-400 text-sm">
结合分子动力学模拟和能量计算，确保设计的抗体具有良好稳定性
</p>
</div>
<div class="text-center">
<div class="w-16 h-16 bg-gradient-to-br from-purple-500 to-purple-600 rounded-2xl flex items-center justify-center mx-auto mb-4">
<span class="text-white text-2xl">🎯</span>
</div>
<h3 class="text-xl font-bold text-white mb-2">亲和力预测</h3>
<p class="text-gray-400 text-sm">
基于结构互补性和相互作用能计算，准确预测抗体-抗原结合亲和力
</p>
</div>
</div>
</div>
</section>
<!-- Footer -->
<footer class="py-12 border-t border-white/10">
<div class="max-w-7xl mx-auto px-6 text-center">
<div class="flex items-center justify-center space-x-3 mb-6">
<div class="w-10 h-10 bg-gradient-to-br from-teal-400 to-orange-500 rounded-lg flex items-center justify-center">
<span class="text-white font-bold text-lg">B</span>
</div>
<span class="text-white text-xl font-bold">BioGen AI</span>
</div>
<p class="text-gray-400 text-sm">
© 2025 BioGen AI. 致力于推动AI驱动的医疗研究创新.
</p>
</div>
</footer>
<script src="main.js"></script>
<script>
// Page-specific initialization
document.addEventListener('DOMContentLoaded', function() {
initializeParameterSliders();
initializeAntibodyGeneration();
});
function initializeParameterSliders() {
const sliders = document.querySelectorAll('.parameter-slider');
sliders.forEach(slider => {
slider.addEventListener('input', function() {
updateSliderValue(this);
});
});
}
function updateSliderValue(slider) {
const value = parseFloat(slider.value);
const sliderIndex = Array.from(document.querySelectorAll('.parameter-slider')).indexOf(slider);
switch(sliderIndex) {
case 0: // Affinity
document.getElementById('affinity-value').textContent = value.toFixed(1) + ' nM';
break;
case 1: // Stability
const stabilityLabels = ['低', '较低', '中等', '较高', '高'];
document.getElementById('stability-value').textContent = stabilityLabels[Math.floor(value * 5) - 1] || '中等';
break;
case 2: // Quantity
document.getElementById('quantity-value').textContent = Math.round(value);
break;
}
}
function initializeAntibodyGeneration() {
const generateBtn = document.getElementById('generate-antibody');
const progressCard = document.getElementById('generation-progress');
const progressBar = document.getElementById('progress-bar');
const progressText = document.getElementById('progress-text');
const resultsDiv = document.getElementById('antibody-results');
const noResultsDiv = document.getElementById('no-results');
generateBtn.addEventListener('click', function() {
const sequence = document.getElementById('antigen-sequence').value.trim();
if (!sequence) {
showNotification('请输入抗原序列', 'error');
return;
}
// Show progress
progressCard.style.display = 'block';
noResultsDiv.style.display = 'none';
// Reset progress
progressBar.style.width = '0%';
progressText.textContent = '0%';
// Simulate generation process
const steps = [
{ progress: 20, text: '分析抗原表位...' },
{ progress: 40, text: '设计CDR区域...' },
{ progress: 60, text: '优化框架区...' },
{ progress: 80, text: '计算亲和力...' },
{ progress: 100, text: '生成完成!' }
];
let currentStep = 0;
const interval = setInterval(() => {
if (currentStep < steps.length) {
const step = steps[currentStep];
progressBar.style.width = step.progress + '%';
progressText.textContent = step.progress + '%';
progressCard.querySelector('.text-gray-400').textContent = step.text;
currentStep++;
} else {
clearInterval(interval);
setTimeout(() => {
progressCard.style.display = 'none';
displayAntibodyResults();
showNotification('抗体生成完成！', 'success');
}, 500);
}
}, 800);
});
}
function displayAntibodyResults() {
const resultsDiv = document.getElementById('antibody-results');
const noResultsDiv = document.getElementById('no-results');
const mockResults = [
{
sequence: 'EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVSAIGTAGDTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGQGLYAMDYWGQGTLVTVSS',
affinity: '0.3 nM',
stability: '96%',
score: 0.94,
cdr1: 'GFTFSSYA',
cdr2: 'IGTAGDT',
cdr3: 'RGQGLYAMDY'
},
{
sequence: 'QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWGWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGGYGDYWGQGTLVTVSS',
affinity: '0.7 nM',
stability: '93%',
score: 0.89,
cdr1: 'GGSISSYA',
cdr2: 'YIYYSGS',
cdr3: 'GGYGDY'
},
{
sequence: 'EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIGTAGDTYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRGQGLYAMDYWGQGTLVTVSS',
affinity: '1.2 nM',
stability: '91%',
score: 0.85,
cdr1: 'GFTFSSYA',
cdr2: 'IGTAGDT',
cdr3: 'RGQGLYAMDY'
},
{
sequence: 'QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSNYDYWGQGTLVTVSS',
affinity: '1.8 nM',
stability: '89%',
score: 0.82,
cdr1: 'GYTFTSYG',
cdr2: 'WISAYNG',
cdr3: 'DSNYDY'
},
{
sequence: 'EVQLVESGGGLVQPGGSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDSNYDYWGQGTLVTVSS',
affinity: '2.1 nM',
stability: '87%',
score: 0.79,
cdr1: 'GFTFDDYA',
cdr2: 'GISWNSG',
cdr3: 'DSNYDY'
}
];
resultsDiv.innerHTML = mockResults.map((result, index) => `
<div class="result-card">
<div class="flex items-center justify-between mb-3">
<h4 class="text-white font-semibold">候选抗体 ${index + 1}</h4>
<div class="flex items-center space-x-2">
<span class="affinity-badge">${result.affinity}</span>
<span class="stability-badge">${result.stability}</span>
</div>
</div>
<div class="space-y-3">
<div>
<div class="text-xs text-gray-400 mb-1">完整序列</div>
<div class="text-gray-300 text-xs font-mono break-all bg-black/20 p-2 rounded">
${result.sequence}
</div>
</div>
<div class="grid grid-cols-3 gap-2 text-xs">
<div>
<div class="text-gray-400">CDR1</div>
<div class="text-teal-400 font-mono">${result.cdr1}</div>
</div>
<div>
<div class="text-gray-400">CDR2</div>
<div class="text-orange-400 font-mono">${result.cdr2}</div>
</div>
<div>
<div class="text-gray-400">CDR3</div>
<div class="text-purple-400 font-mono">${result.cdr3}</div>
</div>
</div>
<div class="flex items-center justify-between pt-2">
<div class="flex-1 bg-gray-700 rounded-full h-2 mr-3">
<div class="bg-gradient-to-r from-teal-500 to-orange-500 h-2 rounded-full" style="width: ${result.score * 100}%"></div>
</div>
<span class="text-white text-sm font-medium">${Math.round(result.score * 100)}分</span>
</div>
<div class="flex space-x-2 mt-3">
<button class="flex-1 bg-teal-500/20 text-teal-400 py-2 px-3 rounded text-xs hover:bg-teal-500/30 transition-colors">
导出序列
</button>
<button class="flex-1 bg-orange-500/20 text-orange-400 py-2 px-3 rounded text-xs hover:bg-orange-500/30 transition-colors">
3D建模
</button>
</div>
</div>
</div>
`).join('');
resultsDiv.style.display = 'block';
noResultsDiv.style.display = 'none';
// Animate results
anime({
targets: '.result-card',
opacity: [0, 1],
translateY: [20, 0],
duration: 600,
delay: anime.stagger(100),
easing: 'easeOutExpo'
});
}
</script>
</body>
</html>