This repository contains code and data supporting the publication:

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

Authors: Saskia Kolb, Leonie Diekmann, Elizabeth E. Lochert, Linda Warmuth, Julia Ritter, Gunter Schmidtke, Michael Weber, Markus Hoffmann, Markus List, Daniel Kotlarz, Isabelle Serr, Carolin Daniel, Dirk H. Busch, Christian Schmidl, Kathrin Schumann*

(*Corresponding author)

Repository Structure

• 📂 data/: Processed datasets used for data analysis
• 📂 lib/: Scripts for data analysis
• 📂 results/: Results from data analyses

Getting Started

Requirements

• Python (≥ 3.8)
• R (≥ 4.0)
• Python packages (listed in requirements.txt)
• R packages (listed in install_packages.R)

Installation

Clone the repository:

git clone https://github.com/daisybio/teff-treg-satb1-analysis.git
cd teff-treg-satb1-analysis

Install dependencies:

pip install -r requirements.txt 
Rscript install_packages.R

Running the Analysis

To reproduce the analyses, run the scripts located in the lib/ directory using the datasets in data/. Processed results can be found in results/.