In this repository is possible to access to the code used in the analysis of the snRNA-seq and spatial transcriptomics (Visium) of the associated manuscript.
- Analysis of the snRNA-seq is available Processing_snRNAseq and snRNA_scVI (Integration of snRNAseq)
- Analysis of the spatial transcriptomics is available Processing_ST and Run_c2l (Deconvolution analysis) and MistyR (Co-localisation/co-exclution analysis)
- The script used to generated all the figures and extended figures is available Generate_Figures. The cytoscape network used to generate figure 2d is available Cytoscape
- The associated functions used for the analysis are available in davidrPackage more information of the content can be found README
The supplementary tables associated to the manuscript are available here.
Vascular niches are the primary hotspots for aging within the multicellular architecture of cardiac tissue. David Rodriguez Morales, Veronica Larcher, Mariano Ruz Jurado, Lukas Tombor, Lukas Zanders, Julian U. G. Wagner, Andreas M. Zeiher, Christoph Kuppe, David John, Marcel Schulz, Stefanie Dimmeler bioRxiv 2025.03.30.646237; doi: https://doi.org/10.1101/2025.03.30.646237