Hypatia

A statistical framework for comparative isoform profiling across cell populations.

To get started, please visit Hypatia's vignette.

About

Hypatia (hi-pay-shuh) is a computational toolkit for the investigation of population-specific isoforms from long-read single-cell RNA-sequencing data, featuring three modes of differential analyses:

1. Isoform usage: Identifies differential isoform usage shifts (DIUs).
2. Isoform diversity: Classifies genes according to isoform species heterogeneity and identifies discrepances (DIVs).
3. Isoform expression: Detects differentially expressed isoforms (DEIs).

Installation

Hypatia is an R library available through Github.

if (!requireNamespace("devtools", quietly = TRUE)) {
  install.packages("devtools")
}

devtools::install_github("gaolabtools/Hypatia")

Requires R version 4.1 or higher.

Citation

If you found Hypatia useful in your research, please cite us:

[Citation]