run Typicalsig to generate 4 typical healthy signature and prevelance csv files:
- matrix_genus_adult.csv
- matrix_species_adult.csv
- matrix_genus_child.csv
- matrix_species_child.csv files are uploaded to Zenodo: https://doi.org/10.5281/zenodo.6342450
run BugSigDBStats.rmd to repriduce analysis for typical signature manuscript