Alzheimers: Add mixed dementias

[NathanielBlairStahn]

• Document adding 94% of mixed dementias to our Alzheimer's prevalence and incidence rates
• Update model runs and V&V tables with proposed model 10.0 run
• Add links to notebooks for models 8.7 and 8.2 that were recently added to vivarium_research_alzheimers

Note: I specified the changes to make in the Data sources and values table, but I did not edit the Vivarium Modeling Strategy section to explain these changes, in order to avoid a merge conflict with #1871. We need to remember to update the text for the modeling strategy, either in that PR or after it's merged.

[NathanielBlairStahn]

@aflaxman I specified running only the Baseline scenario for this update. Does that seem reasonable? If you want to run more scenarios, I can update this.

[aflaxman]

Let's run treatment scenario also, so we can see how this changes our headline results.

[NathanielBlairStahn]

@aflaxman I arbitrarily picked USA and China for the locations to run, but we can change this if we want

[NathanielBlairStahn]

The explanation for "94% of mixed dementias" is as follows: Based on the studies summarized on slides 4 and 5 of this presentation on mixed dementia, it looks like about 94% of mixed dementia cases include Alzheimer's. Specifically, Jaimie said to look at:

• Figure 1 in Brenowitz et al. Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimer’s & Dementia 2017; 13: 654–62.
• Table 2 in Kapasi A, DeCarli C, Schneider JA. Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol 2017; 134: 171–86.

Both studies show similar proportions of >90% AD for mixed dementias. We should note this when we update the Vivarium Modeling Strategy section (e.g. in #1871).

[aflaxman]

ty!

[SylLutze]

FYI I added a line item to the to do list to update the Vivarium Modeling Strategy section so we don't forget about it.