Treatment Updates for Alzheimer's

[SylLutze]

Changes:

• Change in treatment ramp-up from Lilly
• Change in duration of treatment effectiveness for both full and waning impact
• Change in discontinuation to add months to discontinuation and duration of effect dependent on months
• Add observer for months on treatment for those who discontinue

Note: I can't get the graphviz figure to load so I can't tell if it's working... I'm trying to fix it but I want to discuss with engineering so posting this early and I will hopefully update soon.

[NathanielBlairStahn]

So I think this will result in 10% $\times$ (1/8) = 1.25% of people discontinuing each month for the first 8 months, as opposed to 1% discontinuation per month for the first 9 months as Lilly specified (unless I have an off-by-one error or something...). Is that acceptable?

[aflaxman]

I think so

[SylLutze]

This was an intentional choice I made. I realized you can't "discontinue" at 9 months - the treatment lasts for 9 months. So then I could either pick 8% total discontinuation rate, 1% per month, or keep the 10% and not hit the monthly rate they specified. I picked the 10% value.