Sequential activation of PDGF- and TGF-β-signaling in the spatial context of glomerular crescent formation in kidney autoimmunity

The repository contains the code to perform analysis included in the manuscript Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease. The jupyter notebooks and associated scripts are available in the folder "notebooks".

Dependencies

The required Python packages are specified in the environment.yml file. To set up the environment:

conda env create --name <environment_name> -f environment.yml

Citation

Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh, Saskia L. Jauch-Speer, Darius P. Schaub, Jonas Engesser, Malte Hellmig, Vincent Piegsa, Arthur Hube, Varshi Sivayoganathan, Alina Borchers, Anett Peters, Anna Kaffke, Stephanie Zielinski, Hans-Joachim Paust, Thiago Goldbeck-Strieder, Ulrich O. Wenzel, Victor G. Puelles, Elion Hoxha, Thorsten Wiech, Catherine Meyer-Schwesinger, Tobias B. Huber, Ulf Panzer, Stefan Bonn & Christian F. Krebs

Nature Immunology 2025 doi: 10.1038/s41590-025-02291-8.