Tirzepatide model

This repository provides the tirzepatide physiologically based pharmacokinetics (PBPK) model.

The model is distributed as SBML available from tirzepatide_body_flat.xml with the COMBINE archive available from tirzepatide_model.omex.

The model is distributed as SBML available from tirzepatide_body_flat.xml with corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/tirzepatide-model/main/models/tirzepatide_body_flat.xml and equations from tirzepatide_body_flat.md.

The COMBINE archive is available from tirzepatide_model.omex.

Comp submodels

The liver submodel is available from tirzepatide_liver.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/tirzepatide-model/main/models/tirzepatide_liver.xml and equations from tirzepatide_liver.md.

The kidney submodel is available from tirzepatide_kidney.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/tirzepatide-model/main/models/tirzepatide_kidney.xml and equations from tirzepatide_kidney.md.

The whole-body submodel is available from tirzepatide_body.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/tirzepatide-model/main/models/tirzepatide_body.xml and equations from tirzepatide_body.md.

How to cite

Mishra, A., & König, M. (2025). Physiologically based pharmacokinetic (PBPK) model of tirzepatide.
Zenodo. https://doi.org/10.5281/zenodo.14976788

License

• Source Code: MIT
• Documentation: CC BY-SA 4.0
• Models: CC BY-SA 4.0

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

Funding

Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).

© 2025 Abhinav Mishra and Matthias König, Systems Medicine of the Liver