Mapping energy metabolism systems in the human brain

This repository contains code and data used in "Mapping energy metabolism systems in the human brain", available on bioRxiv.

Now published in PLOS Biology.

scripts

The scripts folder conatins all the scripts required to run the analyses described in the manuscript.

data

To be able to run the scripts, please download the following data

• BrainSpan dataset: download "RNA-Seq Gencode v10 summarized to exons" and "Exon microarray summarized to genes"

The data folder includes:

• Structural classes and functional network assignments (Mesulam, Von Economo-Koskinas and Yeo-Krienen) for Schafer-400 and Schaefer-100 parcellations.
• Structural and functional connectivity matrices.
• Cell- and Layer-specific marker genes.
• All other maps used in the analysis including group-average PET and MEG maps and functional connectivity gradients can be retrieved using the neuromaps package with code provided in scripts.

results

The results folder includes outputs generated from the scripts, including the energy expression matrices and mean expression maps.