Obsolete OBA terms referencing obsoleted PRO entities

[Copilot]

Five OBA terms reference protein entities that PRO has obsoleted: PR:000013872, PR:000030596, PR:Q12799, PR:Q6F5E7, and PR:Q9Y4X1.

Changes

• Removed 5 entries from entity_attribute_location.tsv pattern data
• Added 5 entries to obsoletes.tsv with obsoletion rationale
• Regenerated definitions.owl and components/obsoletes.owl

Obsoleted Terms

OBA ID	PRO ID	Protein
OBA:2043233	PR:000013872	regenerating islet-derived protein 3-gamma
OBA:2044443	PR:000030596	putative uncharacterized protein TXNRD3NB
OBA:2058599	PR:Q12799	putative T-complex protein 10A homolog (human)
OBA:2059278	PR:Q6F5E7	putative uncharacterized protein TXNRD3NB (human)
OBA:2081815	PR:Q9Y4X1	UDP-glucuronosyltransferase 2A1 (human)

All terms now carry owl:deprecated="true" with comments referencing the obsoleted PRO entities.

Original prompt

---

This section details on the original issue you should resolve

<issue_title>Fix OBA terms with obsoleted entities</issue_title>
<issue_description>Entities in the following terms have been obsoleted by the Protein Ontology:

OBA:2081815
OBA:2043233
OBA:2044443
OBA:2059278
OBA:2058599</issue_description>

Comments on the Issue (you are @copilot in this section)

• Fixes Fix OBA terms with obsoleted entities #405

---

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[ar-ibrahim]

@copilot Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

[Copilot]

@copilot Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

Here's the list of obsoleted PRO terms with replacement suggestions:

OBA Term	Obsolete PRO ID	Protein Name	Replacement	Notes
OBA:2081815	PR:Q9Y4X1	UDP-glucuronosyltransferase 2A1 (human)	PR:P0DTE4	Formal replacement available
OBA:2043233	PR:000013872	regenerating islet-derived protein 3-gamma	PR:Q6UW15 (human-specific)	Gene-level term obsoleted due to paralogs; human archetype exists
OBA:2044443	PR:000030596	putative uncharacterized protein TXNRD3NB	None	Withdrawn from UniProtKB - protein doesn't exist
OBA:2058599	PR:Q12799	putative T-complex protein 10A homolog (human)	None	Based on pseudogene - not a real protein
OBA:2059278	PR:Q6F5E7	putative uncharacterized protein TXNRD3NB (human)	None	Withdrawn from HGNC - protein doesn't exist

Recommendation:

• For OBA:2081815, consider creating a new term using PR:P0DTE4 if measurements of this protein are still relevant
• For OBA:2043233, the human-specific PR:Q6UW15 could replace the obsolete gene-level term if human data is being measured
• For the remaining three terms, no replacements are available as the proteins were determined to not exist

[ar-ibrahim]

@copilot I added 4 OBA terms to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

[Copilot]

@copilot I added 4 OBA terms to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

I'd be happy to check for obsoleted PRO terms and suggest replacements. However, I cannot see the 4 additional OBA terms you mentioned adding to the issue. Could you please provide the OBA term IDs (e.g., OBA:XXXXXXX) so I can investigate them?

Alternatively, if you can share:

• The OBA term IDs, or
• The PRO (Protein Ontology) IDs they reference, or
• A screenshot or paste of the updated issue description

I'll be able to check the PRO import for obsoletion status and suggest replacements where available.

[ar-ibrahim]

@copilot These are the OBA IDs I added to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

OBA:1000220
OBA:1000596
OBA:1000264
OBA:1000294

[ar-ibrahim]

@copilot These are the OBA IDs I added to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

OBA:1000220
OBA:1000596
OBA:1000264
OBA:1000294

[Copilot]

@copilot These are the OBA IDs I added to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

OBA:1000220
...

I've investigated these 4 OBA terms. They reference GO (Gene Ontology) terms for biological processes, not PRO (Protein Ontology) terms. None of the referenced GO terms are obsolete:

OBA ID	Referenced Ontology	Entity ID	Entity Name	Status
OBA:1000220	GO	GO:0009069	serine family amino acid metabolic process	✅ Active
OBA:1000596	GO	GO:0009066	aspartate family amino acid metabolic process	✅ Active
OBA:1000264	GO	GO:0006486	protein glycosylation	✅ Active
OBA:1000294	GO	GO:0070085	glycosylation	✅ Active

Conclusion: These terms are all valid and do not need to be obsoleted. They're using the entity_attribute_part_of pattern with active GO process terms, not obsolete PRO protein terms.

This PR specifically addresses OBA terms that reference obsolete PRO entities (proteins), which are the 5 terms already handled: OBA:2081815, OBA:2043233, OBA:2044443, OBA:2059278, and OBA:2058599.

@copilot These are the OBA IDs I added to the issue. Make a list of the obsoleted PR terms and suggest replacements from the Protein Ontology.

OBA:1000220...

I've investigated these 4 OBA terms. They reference GO (Gene Ontology) terms for biological processes, not PRO (Protein Ontology) terms. None of the referenced GO terms are obsolete:

OBA ID	Referenced Ontology	Entity ID	Entity Name	Status
OBA:1000220	GO	GO:0009069	serine family amino acid metabolic process	✅ Active
OBA:1000596	GO	GO:0009066	aspartate family amino acid metabolic process	✅ Active
OBA:1000264	GO	GO:0006486	protein glycosylation	✅ Active
OBA:1000294	GO	GO:0070085	glycosylation	✅ Active

Conclusion: These terms are all valid and do not need to be obsoleted. They're using the entity_attribute_part_of pattern with active GO process terms, not obsolete PRO protein terms.

This PR specifically addresses OBA terms that reference obsolete PRO entities (proteins), which are the 5 terms already handled: OBA:2081815, OBA:2043233, OBA:2044443, OBA:2059278, and OBA:2058599.

[ar-ibrahim]

@copilot These 4 GO terms have been obsoleted. Check again and suggest appropriate replacement terms from GO.

[Copilot]

@copilot These 4 GO terms have been obsoleted. Check again and suggest appropriate replacement terms from GO.

You're correct - I apologize for the confusion. The GO import in this repository is from 2022-01-19 and may be outdated. The 4 GO terms appear active in the current import file, but if they've been obsoleted after that date, the import needs to be refreshed first.

Here's what I found in the current import:

• GO:0009069 - serine family amino acid metabolic process (appears active)
• GO:0009066 - aspartate family amino acid metabolic process (appears active)
• GO:0006486 - protein glycosylation (appears active)
• GO:0070085 - glycosylation (appears active)

To proceed, I need:

1. Can you confirm the replacement GO terms for each of these? Or,
2. Should the GO import be refreshed first to get the latest obsoletions and replacements?

Once I have the correct replacement terms, I can obsolete these 4 OBA terms (OBA:1000220, OBA:1000596, OBA:1000264, OBA:1000294) and optionally create new OBA terms using the replacement GO terms.

[aleixpuigb]

HI @ar-ibrahim, is there any progress with this issue? I ahve created some terms in Uberon that I need to import to OBA but this is blocking it. Thanks!

[ar-ibrahim]

Hi @aleixpuigb. Yes I was working on other projects but will fix this so that it's not a blocker!