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Update S cell (CL_0002281) with detailed functional, morphological, and recent transcriptomic evidence #3551

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Update S cell (CL_0002281) with detailed functional, morphological, and recent transcriptomic evidence #3551

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87c778a
Initial plan
Copilot Jan 8, 2026
3babe92
Update S cell (CL_0002281) definition with detailed functional and mo…
Copilot Jan 8, 2026
036c0a2
Address code review feedback: use American spelling and clarify SCT a…
Copilot Jan 8, 2026
6eed916
added in text refs and a missing ref
Caroline-99 Jan 16, 2026
3a3b7a6
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 5, 2026
90d0c94
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 5, 2026
091c686
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 12, 2026
654d480
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 12, 2026
51622e1
Added GO term for detection of chemical stimulus
RiveraAndrea83 Feb 16, 2026
12f0e2f
Fixed obsoleted GO terms
RiveraAndrea83 Feb 16, 2026
52c5bd7
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 16, 2026
71bc03b
Fixed axiomatisation
RiveraAndrea83 Feb 17, 2026
9eb66c5
Fixed GO terms
RiveraAndrea83 Feb 17, 2026
cf87886
Update hra_subset.owl
dosumis Feb 17, 2026
58cc596
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 19, 2026
1b6bbcd
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Feb 19, 2026
2a133a2
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Mar 11, 2026
cf92a36
Merge branch 'master' into copilot/add-s-cell-definition
RiveraAndrea83 Mar 18, 2026
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6 changes: 5 additions & 1 deletion src/ontology/cl-edit.owl
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Original file line number Diff line number Diff line change
Expand Up @@ -3361,6 +3361,7 @@ Declaration(Class(obo:GO_0046697))
Declaration(Class(obo:GO_0046930))
Declaration(Class(obo:GO_0050893))
Declaration(Class(obo:GO_0050956))
Declaration(Class(obo:GO_0050974))
Declaration(Class(obo:GO_0050981))
Declaration(Class(obo:GO_0051216))
Declaration(Class(obo:GO_0060083))
Expand Down Expand Up @@ -17069,15 +17070,18 @@ SubClassOf(obo:CL_0002280 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000190

# Class: obo:CL_0002281 (type S enteroendocrine cell)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:15153415") obo:IAO_0000115 obo:CL_0002281 "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref <https://www.ncbi.nlm.nih.gov/books/NBK54132/>) Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:15153415") Annotation(oboInOwl:hasDbXref "PMID:21518048") Annotation(oboInOwl:hasDbXref "PMID:30725969") Annotation(oboInOwl:hasDbXref "PMID:37240181") obo:IAO_0000115 obo:CL_0002281 "An enteroendocrine cell of the small intestine that secretes secretin into the bloodstream in response to decreased luminal pH (below ~4.5) (Parikh & Thevenin, 2023). This cell is an open-type cell, characterised by apical microvilli that extend to the intestinal lumen, allowing direct detection of luminal contents (Pandol, 2010; Atanga et al., 2023). This cell regulates duodenal pH by stimulating pancreatic bicarbonate secretion, inhibiting gastric acid secretion and gastric emptying, and promoting biliary secretion (Atanga et al., 2023). S cells are scattered throughout the duodenojejunal epithelium, with the highest density in the duodenum.")
AnnotationAssertion(terms:contributor obo:CL_0002281 <https://orcid.org/0000-0003-1980-3228>)
AnnotationAssertion(oboInOwl:creation_date obo:CL_0002281 "2010-09-10T04:44:46Z"^^xsd:dateTime)
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002281 "FMA:62936")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002281 "S cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38866945") rdfs:comment obo:CL_0002281 "Recent single-cell transcriptomic analyses in both mice and humans demonstrate that SCT (secretin) expression is not restricted to a single distinct cell population but rather is co-expressed across multiple mature enteroendocrine cell subtypes, particularly K, N, I, and L cells, challenging the traditional 'one cell-one hormone' classification.")
AnnotationAssertion(rdfs:label obo:CL_0002281 "type S enteroendocrine cell")
SubClassOf(obo:CL_0002281 obo:CL_0000164)
SubClassOf(obo:CL_0002281 obo:CL_0000167)
SubClassOf(obo:CL_0002281 obo:CL_0000458)
SubClassOf(obo:CL_0002281 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902))
SubClassOf(obo:CL_0002281 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0009593))

# Class: obo:CL_0002282 (type TG enteroendocrine cell)

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2 changes: 1 addition & 1 deletion src/ontology/components/hra_subset.owl
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Original file line number Diff line number Diff line change
Expand Up @@ -5570,5 +5570,5 @@



<!-- Generated by the OWL API (version 4.5.29.2024-05-13T12:11:03Z) https://github.com/owlcs/owlapi -->
<!-- Generated by the OWL API (version 4.5.25.2023-02-15T19:15:49Z) https://github.com/owlcs/owlapi -->

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