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Add NA imputation options (#541)#888

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Gero1999 wants to merge 17 commits intomainfrom
541-feat-na-imputation-options
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Add NA imputation options (#541)#888
Gero1999 wants to merge 17 commits intomainfrom
541-feat-na-imputation-options

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@Gero1999 Gero1999 commented Jan 13, 2026

Issue

Contributes to #541

Description

Using same strategy as BLQ imputation (#491) through PKNCA to perform NA imputation before BLQ imputation only on non-observational parameters by setting it in the impute column (intervals: update_main_intervals) and then running NCA (PKNCA_calculate_nca)

Definition of Done

  • Option for user to select NA imputation, including option for None, Drop or Impute Value at least

How to test

Contributor checklist

  • Code passes lintr checks
  • Code passes all unit tests
  • New logic covered by unit tests
  • New logic is documented
  • App or package changes are reflected in NEWS
  • Package version is incremented

Notes to reviewer

My intuition says that this implementation can have substantial issues due to how we handled so far with NAs. If possible, please document thoughtfully any error you find so it can be easily replicated

@Gero1999 Gero1999 linked an issue Jan 13, 2026 that may be closed by this pull request
2 tasks
@Gero1999 Gero1999 changed the title 541 feat na imputation options Add NA imputation options (#541) Jan 14, 2026
Gero1999 and others added 6 commits January 14, 2026 11:17
…n-options (accept both changes and add end of fun)
…e-tracking branch 'origin/main' into 541-feat-na-imputation-options)
…R, remote-tracking branch 'origin/139-feat/blq-options' into 541-feat-na-imputation-options
…in PKNCA_impute_method_blq when possible) remote-tracking branch 'origin/main' into 541-feat-na-imputation-options
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Feat: NA imputation Options

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