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Allow duplicates to not count against multiplicity - #5033

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faithokamoto wants to merge 2 commits into
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better-multi-dup
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Allow duplicates to not count against multiplicity#5033
faithokamoto wants to merge 2 commits into
masterfrom
better-multi-dup

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Changelog Entry

To be copied to the draft changelog by merger:

  • vg giraffe chaining mode removes overlapping chains from multiplicity calculation

Description

Wheee another MAPQ bugfix. I'll run alignment & variant calling comparisons before merging.

We use multiplicity to count the number of independent as-good things. However we only check for independence if we get all the way to alignment; there's an earlier step where we toss out chains if they overlap a previous alignment. That seems like a pretty non-independent event. Thus here we make sure to decrement multiplicity as makes sense.

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