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Genomics Division, ITER edited this page Aug 4, 2020 · 16 revisions

COVID-19

A public repository of scientific and media resources of SARS-CoV-2 related COVID-19 maintained by ITER.

Virology

Section to describe the different mechanisms and tropism that the virus displays. Under construction...

A gene locus that controls expression of ACE2 in virus infection

A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein

A previously uncharacterized gene in SARS-CoV-2 and the origins of the COVID-19 pandemic

Another Decade, Another Coronavirus

A single-cell atlas of the peripheral immune response to severe COVID-19

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

ACE2: from vasopeptidase to SARS virus receptor

ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia

ACE2 shedding and furin abundance in target organs may influence the efficiency of SARS-CoV-2 entry

ACE2: The Only Thing That Matters?

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

Airway expression of SARS-CoV-2 receptor, ACE2, and proteases, TMPRSS2 and furin, in severe asthma

Analysis the susceptibility of lung cancer patients to SARS-CoV-2 infection

Angiotensin‐converting enzyme 2 (ACE2) as a SARS‐CoV‐2 receptor: molecular mechanisms and potential therapeutic target

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

Bioinformatics Study on Structural Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) For Better Understanding the Vaccine Development

CD147/EMMPRIN Acts as a Functional Entry Receptor for Measles Virus on Epithelial Cells

Characterization of intra-host SARS-CoV-2 variants improves phylogenomic reconstruction and may reveal functionally convergent mutations

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses

Comparison of Commercially Available and Laboratory Developed Assays for in vitro Detection of SARS-CoV-2 in Clinical Laboratories

Complement as a target in COVID-19?

Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

Coronavirus envelope protein: current knowledge

Coronavirus infections and immune responses

COVID‐19 in the heart and the lungs: could we “Notch” the inflammatory storm?

COVID-19. Transport of respiratory droplets in a microclimatologic urban scenario

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Cyclophilin–CD147 interactions: a new target for anti-inflammatory therapeutics

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Elucidating the differences in the molecular mechanism of receptor binding between 2019-nCoV and the SARS-CoV viruses using computational tools

Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

Evolutionary stasis of viruses? | Reply to ‘Evolutionary stasis of viruses?’

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays

Expression of SARS-CoV-2 receptor ACE2 and the spike protein processing enzymes in developing human embryos

Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

Infection of dogs with SARS-CoV-2

Individual variation of the SARS-CoV2 receptor ACE2 gene expression and regulation

Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Interaction of drugs candidates with various SARS-CoV-2 receptors: an in silico study to combat COVID-19

Is COVID-19 receiving ADE from other coronaviruses?

Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Mechanistic modeling of the SARS-CoV-2 disease map

Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial

Molecular characterization of SARS-CoV-2 in the first COVID-19 cluster in France reveals an amino-acid deletion in nsp2 (Asp268Del)

Novel ACE2-Independent Carbohydrate-Binding of SARS-CoV-2 Spike Protein to Host Lectins and Lung Microbiota

Origin and evolution of pathogenic coronaviruses

Pandemics: spend on surveillance, not prediction

Persistent viral shedding of SARS-CoV-2 in faeces - a rapid review

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

Prisoners of war — host adaptation and its constraints on virus evolution

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

Profile of a killer: the complex biology powering the coronavirus pandemic

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

SARS Coronavirus Redux

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

SARS-CoV-2 Life Cycle: Stages and Inhibition Targets

SARS-CoV-2 productively infects human gut enterocytes

SARS-CoV-2 receptor ACE2 and TMPRSS2 are predominantly expressed in a transient secretory cell type in subsegmental bronchial branches

SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade

Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Structural basis of receptor cognition by SARS-CoV-2

Structural Basis of SARS-CoV-2 Spike Protein Priming by TMPRSS2

Structural analysis of SARS-CoV-2 and predictions of the human interactome

Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Structure of replicating SARS-CoV-2 polymerase

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2

Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

The biology of influenza viruses

The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS

The proximal origin of SARS-CoV-2

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus

Tracking virus outbreaks in the twenty-first century

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

Unveiling diffusion pattern and structural impact of the most invasive SARS-CoV-2 spike mutation

Viral and host factors related to the clinical outcome of COVID-19

Viral dynamics in mild and severe cases of COVID-19

Viral load of SARS-CoV-2 in clinical samples

We shouldn’t worry when a virus mutates during disease outbreaks

Why do RNA viruses recombine?

Widely available lysosome targeting agents should be considered as a potential therapy for COVID-19

Animal Models & Epizootic Infections

A Comprehensive Review of Animal Models for Coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

A versatile mouse model of COVID-19

Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets

ARDS and Cytokine Storm in SARS-CoV-2 Infected Caribbean Vervets

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

Comparison of SARS-CoV-2 spike protein binding to ACE2 receptors from human, pets, farm animals, and putative intermediate hosts

Establishment of an African green monkey model for COVID-19

Infection and Rapid Transmission of SARS-CoV-2 in Ferret

Infection of bat and human intestinal organoids by SARS-CoV-2

Infection of dogs with SARS-CoV-2

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques

SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

Evolution & Phylogenetics

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

A new coronavirus associated with human respiratory disease in China

A planarian nidovirus expands the limits of RNA genome size

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2

Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

Assembly of an integrated human lung cell atlas reveals that SARS-CoV-2 receptor is co-expressed with key elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Conserved Genomic Terminals of SARS-CoV-2 as Co-evolving Functional Elements and Potential Therapeutic Targets

Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily

Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisation

Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans

Genomic Analysis of Early SARS-CoV-2 Variants Introduced in Mexico

High‐Coverage SARS‐CoV‐2 Genome Sequences Acquired by Target Capture Sequencing

Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates

Identification of super-transmitters of SARS-CoV-2

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Genotyping coronavirus SARS-CoV-2: Methods and implications

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2

Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands

RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look

Sarbecovirus comparative genomics elucidates gene content of SARS-CoV-2 and functional impact of COVID-19 pandemic mutations

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics

Six reference-quality genomes reveal evolution of bat adaptations

Snapshot of the evolution and mutation patterns of SARS-CoV-2

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera

The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses

Virus Isolation from the First Patient with SARS-CoV-2 in Korea

Host Immune Response

A possible role of immunopathogenesis in COVID-19 progression

A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding

An inflammatory cytokine signature helps predict COVID-19 severity and death

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

Anti-Spike, anti-Nucleocapsid and neutralizing antibodies in SARS-CoV-2 hospitalized patients and asymptomatic carriers

Autoinflammatory and autoimmune conditions at the crossroad of COVID-19

Beyond the Spike: identification of viral targets of the antibody response to SARS-CoV-2 in COVID-19 patients

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Comprehensive mapping of immune perturbations associated with severe COVID-19

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19

Cytokine biomarkers of COVID-19

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients

Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions

Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients

Gut microbiota may underlie the predisposition of healthy individuals to COVID-19

High levels of SARS-CoV-2 specific T-cells with restricted functionality in patients with severe course of COVID-19

High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay

Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Immunogenic profile of SARS-CoV-2 spike in individuals recovered from COVID-19

Immune Response to SARS-CoV-2 and Mechanisms of Immunopathological Changes in COVID-19

Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis

Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease

Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

Platelet activation and platelet-monocyte aggregates formation trigger tissue factor expression in severe COVID-19 patients

Potently neutralizing and protective human antibodies against SARS-CoV-2

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course

SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients

Serum protein profiling reveals a landscape of inflammation and immune signaling in early-stage COVID-19 infection

Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cells

Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

Study on the expression levels of antibodies against SARS-CoV-2 at different period of disease and its related factors in 192 cases of COVID-19 patients

Symptomatic SARS-CoV-2 infections display specific IgG Fc structures

Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

The SARS-CoV-2 T-cell immunity is directed against the spike, membrane, and nucleocapsid protein and associated with COVID 19 severity

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Viral and host factors related to the clinical outcome of COVID-19

Will we see protection or reinfection in COVID-19?

Proteins & Translation

A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot

Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes

Critical Differences Between the Binding Features of the Spike Proteins of SARS-CoV-2 and SARS-CoV

Cytologic and molecular correlates of SARS-CoV-2 infection of the nasopharynx

Data, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

Integrative Vectors for Regulated Expression of SARS-CoV-2 Proteins Implicated in RNA Metabolism

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in vitro models of the human blood-brain barrier

RNA Replication

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Nidovirales: evolving the largest RNA virus genome

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum

Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease, United States

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase

Structure of replicating SARS-CoV-2 polymerase

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Virus Assembly, Protein Processing and Structure

A direct RNA-protein interaction atlas of the SARS-CoV-2 RNA in infected human cells

A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates

An Infectious cDNA Clone of SARS-CoV-2

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein

Companion vaccine Bioinformatic design tool reveals limited functional genomic variability of SARS-Cov-2 Spike Receptor Binding Domain

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Deducing the N- and O- glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2

Discovery of G-quadruplex-forming sequences in SARS-CoV-2

High-surety isothermal amplification and detection of SARS-CoV-2, including with crude enzymes Identification of common deletions in the spike protein of SARS-CoV-2

Ligand-centered assessment of SARS-CoV-2 drug target models in the Protein Data Bank

Modeling and Simulation of a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically-Sensitive Activation Loop

Self-Collected Oral Fluid and Nasal Swabs Demonstrate Comparable Sensitivity to Clinician Collected Nasopharyngeal Swabs for Covid-19 Detection

Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

Structural analysis of the putative SARS-CoV-2 primase complex

Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS-CoV-2

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine

The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types

The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase enzyme

The sprint to solve coronavirus protein structures — and disarm them with drugs

Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage

Viral Entry & Receptors

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19

Controlling the SARS-CoV-2 spike glycoprotein conformation

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance

Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

Distinct conformational states of SARS-CoV-2 spike protein

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atoms Simulations

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

LY6E impairs coronavirus fusion and confers immune control of viral disease

LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

Neuropilin-1 is a host factor for SARS-CoV-2 infection

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

SARS-CoV-2, SARS-CoV-1 and MERS-CoV viral load dynamics, duration of viral shedding and infectiousness: a living systematic review and meta-analysis

SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

SARS-CoV-2 viral load in the upper respiratory tract of children and adults with early acute COVID-19

Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models

SARS-CoV-2 productively infects human gut enterocytes

SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

Shielding and Beyond: The Roles of Glycans in SARS-CoV-2 Spike Protein

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity

Site-specific glycan analysis of the SARS-CoV-2 spike

Structural and functional basis of SARS-CoV-2 entry by using human ACE2

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

The SARS-CoV-2 Spike Variant D614G Favors an Open Conformational State

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

Viral Replicate/Non-Structural Proteins/Enzymes

An in silico map of the SARS-CoV-2 RNA Structurome

A molecular pore spans the double membrane of the coronavirus replication organelle

Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

Crystal structures of SARS-CoV-2 ADP-ribose phosphatase (ADRP): from the apo form to ligand complexes

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

Genetic architecture of host proteins interacting with SARS-CoV-2

Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease

Molecular Basis for ADP-ribose Binding to the Mac1 Domain of SARS-CoV-2 Nsp3

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

Replication of Severe Acute Respiratory Syndrome Coronavirus 2 in Human Respiratory Epithelium

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

By JMLS @resocios

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